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ISTH 2020 Congress

July 12-14, 2020. Virtual Congress.

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  • Abstract Number: LB/CO01.1

    A Novel Adeno Associated Virus (AAV) Gene Therapy (FLT180a) Achieves Normal FIX Activity Levels in Severe Hemophilia B (HB) Patients (B-AMAZE Study)

    P. Chowdary1,2, S. Shapiro3, M. Makris4, G. Evans5, S. Boyce6, K. Talks7, G. Dolan8, U. Reiss9, M. Phillips1, A. Riddell1, M.R. Peralta1, M. Quaye2, E. Tuddenham1, J. Krop10, G. Short11, S. Kar11, A. Smith11, A. Nathwani1,2

  • Abstract Number: LB/CO01.2

    Thrombosis, Bleeding, and the Effect of Anticoagulation on Survival in Critically Ill Patients with COVID-19 in the United States

    H. Al-Samkari1,2, S. Gupta2,3, R. Karp Leaf1,2, W. Wang4, R. Rosovsky1,2, K. Bauer2,5, D. Leaf2,3, STOP-COVID Investigators

  • Abstract Number: LB/CO01.3

    Incidence of Venous Thromboembolism in Patients Discharged after COVID-19 Hospitalisation

    M.M. Engelen, T. Vanassche, T. Balthazar, E. Claeys, J. Gunst, M. Jacquemin, S. Janssens, N. Lorent, L. Liesenborghs, K. Peerlinck, G. Pieters, S. Rex, P. Sinonquel, L. Van der Linden, C. Van Laer, R. Vos, J. Wauters, A. Wilmer, P. Verhamme, C. Vandenbriele

  • Abstract Number: LB/CO01.4

    Higher Incidence of Thrombotic Complications in Hospitalized Patients with SARS-COV-2 Virus versus Influenza Virus Infections

    M.A.M. Stals1, M.J.J.H. Grootenboers2, C. van Guldener3, F.H.J. Kaptein1, S.J.E. Braken1, Q. Chen4, G. Chu1, E.M. van Driel5, A. Iglesias del Sol6, F. Pals1, M.M.A. Toorop4, S.C. Cannegieter1,4, F.A. Klok1, M.V. Huisman1

  • Abstract Number: OC 01.1

    von Willebrand Factor as a Predictor of Mortality and its Target Concentration Dependent Inhibition by BT200 Aptamer in Patients Treated with Potent ADP Receptor Blockers

    K. Kovacevic1, B. Jilma1, S. Zhu2, J. C. Gilbert2, M.-P. Winter3, A. Toma3, I. Lang3, C. Hengstenberg3, J. Siller-Matula4

  • Abstract Number: OC 01.2

    Low-grade Endotoxaemia Enhances Artery Thrombus Growth via Toll-like Receptor 4: Implication for Myocardial Infarction

    C. Nocella1, R. Carnevale2, S. Sciarretta2, V. Cammisotto2, V. Valenti2, C. Calvieri2, G. Frati2, G. D'Amati2, R. Cangemi2, A. Arrivi3, M. Dominici3, E. Mangeri2, C. Gaudio2, G. Tanzilli2, F. Violi2

  • Abstract Number: OC 01.3

    Unraveling the Protective Effects of Factor Xa Inhibition by Rivaroxaban on Atherosclerosis by RNA Sequencing

    J.J. Posma1, R. Van Oerle1, A.C. Cleuren2, M.A. Van der Ent2, A. Isaacs3, M. Stoll4,5, H. Ten Cate1,6, H.M. Spronk1

  • Abstract Number: OC 01.4

    Reduction of Intracellular Sodium Protects from Inflammation and Atherosclerotic Plaque Progression

    M. Lenz1, C. Kaun1, A. Rehberger2, M. Sebestjen2, C. Binder3, K. Huber4, C. Hengstenberg1, J. Wojta1, W. Speidl1, P. Hohensinner1

  • Abstract Number: OC 01.5

    Impact of Platelet-Selective TGF-β1-Deficiency in Atherogenesis and CD4+ T Effector Responses Using a No-Germline Genetic Engineering Atherosclerosis Mouse Model

    S. Tan1, Y. Sun2, A. Gisterå1, Y. Min1, J. Zhang1, C. Ma2, N. Li1

  • Abstract Number: OC 02.1

    Fibrin γ-chain Crosslinking Plays an Important Role in Preventing Thrombus Breakdown and Embolisation in-vivo

    C. Duval1, A. Baranauskas1, M. Ali1, Z. Raslan1, S.R. Baker1, H.R. McPherson1, M.A. Bailey1, R.M. Cubbon1, R.A. Ajjan1, H. Philippou1, K.K. Naseem1, V.C. Ridger2, R.A.S. Ariëns1

  • Abstract Number: OC 02.2

    Chemical Modulation of Fibrinogen Production and its Impact on Venous Thrombosis

    R. Vilar1, S.W. Lukowski2, M. Garieri1, C. Di Sanza1, M. Neerman-Arbez1,3, R.J. Fish1

  • Abstract Number: OC 02.3

    FXIII Catalyses Histone-Fibrin Crosslinking to Inhibit Fibrinolysis

    M. Locke, C. Longstaff

  • Abstract Number: OC 02.4

    Fibrinogen Is Citrullinated in Venous Thrombi and Forms Fragile Clots with Increased Resistance to Lysis

    I. Varju1,2,3, N. Sorvillo2,4, D. Cherpokova2,4, V.J. Farkas1, A.Z. Farkas1, E. Komorowicz1, T. Feller5, B. Kiss5, M.S. Kellermayer5, L. Szabo6, A. Wacha7, A. Bota7, C. Longstaff8, D.D. Wagner2,4,9, K. Kolev1

  • Abstract Number: OC 02.5

    Low α2-plasmin Inhibitor Antigen Levels on Admission Predict Unfavorable Outcomes in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

    R. Orbán-Kálmándi1, B. Baráth1, F. Sarkady1, E. Székely1, I. Szegedi2, K.R. Czuriga-Kovács2, I. Fekete2, K. Fekete2, É. Katona1, L. Csiba2, Z. Bagoly1,3

  • Abstract Number: OC 03.1

    Immune Profiling of Previously Untreated Patients with Severe Haemophilia A by High-throughput Mimotope Variation Analysis

    G. Baselli1, R. Palla2, C. Valsecchi3, K. Palm4, S. Miri5, F. Peyvandi2,3, SIPPET Study Group

  • Abstract Number: OC 03.2

    Final Results of PUPs A-LONG Study: Evaluating Safety and Efficacy of rFVIIIFc in Previously Untreated Patients with Haemophilia A

    C. Königs1, M.C. Ozelo2, A. Dunn3, R. Kulkarni4, B. Nolan5, S.A. Brown6, R. Liesner7, M. Schiavulli8, S. Gunawardena9, S. Mukhopadhyay10, D. Jayawardene9, B. Winding11, M. Carcao12

  • Abstract Number: OC 03.3

    Deciphering the Ets-1/2-mediated Transcriptional Regulation of F8 Gene Identifies a Minimal F8 Promoter for Hemophilia A Gene Therapy

    R. Famà1, E. Borroni1, S. Merlin1, S. Pignani1, C. Airoldi2, A. Cucci1, V. Bruscaggin1, S. Scardellato1, M. Pinotti3, G.E. Walker1, A. Follenzi1

  • Abstract Number: OC 03.4

    First In Human Liver Biopsy Study Following Gene Therapy for Hemophilia A

    S. Fong1, S. Rangarajan2, N. Mitchell1, C.-R. Sihn1, B. Yates1, R. Torres1, C. Russell1, K.J. Pasi3, A. Lawal1, B. Kim1, S. Bunting1, G. Pierce4, W.Y. Wong1

  • Abstract Number: OC 03.5

    Phase I/II Trial of SPK-8011: Stable and Durable FVIII Expression for >2 Years with Significant ABR Improvements in Initial Dose Cohorts Following AAV-Mediated FVIII Gene Transfer for Hemophilia A

    L. George1,2, E. Eyster3, M. Ragni4, S. Sullivan5, B. Samelson-Jones1,2, M. Evans3, A. MacDougall6, M. Curran6, S. Tompkins6, K. Wachtel6, D. Takefman6, K. Reape6, F. Mingozzi6, P. Monahan6, X. Anguela6, K. High6

  • Abstract Number: OC 04.1

    Moderate Platelet Defects but Efficiently Restored Thrombopoietin Production Early after Partial Hepatectomy via JAK2-STAT3 Signaling in Mice

    F. Reusswig1, N. Fazel Modares2, M. Brechtenkamp3, I. Krueger3, D. Herebian4, D. Häussinger5, J. Scheller2, M. Elvers3

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