ISTH 2021 Congress Archives - ISTH Congress Abstracts

Abstract Number: PB0336

Laboratory Assessment of DOAC Assays for FXa Inhibitors in the Presence of Reversal Agent Andexanet Alfa on the ACL TOP/TOP 50 Coagulation Analyzers

A. Khan¹, K. Shishko¹, G. Lu², V. Nguyen¹, A. Winkler¹
Abstract Number: PB1099

Laboratory Monitoring of Coagulation State in Children with Acute Lymphoblastic Leukemia

E. Seregina^1,2, L. Zharikova¹, N. Trubina¹, M. Korsantiya¹, M. Gracheva¹, A. Poletaev¹, T. Vuimo^1,2, F. Ataullakhanov^1,2,3,4, U. Rumyantseva¹, A. Karachunskiy¹
Abstract Number: PB0485

Laboratory Monitoring of Emicizumab in Treated Patients – How Does APTT Compare?

A. McCormick¹
Abstract Number: PB0394

Laboratory Testing in Patients Treated with Direct Oral Anticoagulants: Our Experience

G. Garcia-Donas¹, M. García¹, M. Bonete¹, A. Rodríguez¹
Abstract Number: PB1067

Laboratory Testing Platform Discrepancy between Current Singleplex-assay and New Multiplex-assay for Detecting and Quantifying IgM-anti-Cardiolipin-antibodies and other Anti-Phospholipid (APL)-antibodies: The Potential for Mis-diagnosis of the APL-syndrome

M. Escobar¹, T.E. Howard², N. Montanez¹
Abstract Number: PB0478

Laboratory Verification of a Chromogenic Factor IX Assay Kit

J. Tange¹, M. Sridharan¹, N. Heikal¹, D. Chen¹, R. Pruthi¹
Abstract Number: PB0672

Late Prophylaxis in Severe Hemophilia A: Effect on Functional Abilities

M. Sousa-Pimenta^1,2, L. Soares Miranda¹, J. Ferreira¹, A. Barros¹, M. Coutinho¹, S. Morais¹, E. Cruz¹
Abstract Number: PB0583

Left Atrial Appendage Occlusion for the Management of Atrial Fibrillation in Persons with Hemophilia: A Case Report and Systematic Review of the Literature

M.Y. Lim¹, M.Y. Abou-Ismail¹
Abstract Number: PB0819

Length of Thrombopoietin Receptor Agonist (TPO-RA) Treatment and Persistence in Immune Thrombocytopenia (ITP): Real World United States Claims Analyses

M. Vredenburg¹, S. Kolodny¹, M. Wojdyla¹, H. Boyer¹, T. Darden¹
Abstract Number: PB0026

Leo Buerger’s Disease: About 13 Cases

I. Chabchoub¹, R. Ben Salah¹, N. Regaieg¹, F. Frikha¹, Z. Bahloul¹
Abstract Number: PB0440

Life-threatening Bleeding in Acquired Factor V Inhibitor Can Be Controlled Combining Platelet Transfusion and Recombinant Activated Factor VII Administration

V. Robles¹, C.A. Dávalos¹, L.M. Serrano¹, J. Torres¹, R. Fernández¹, P. Chamorro¹, M.P. Chávez¹, C. Fernández¹
Abstract Number: PB0895

Light Transmission Aggregometry (LTA) on TA-8V (Stago^®): What about Normal Values?

A. Dericquebourg¹, M. Daniel², J.-C. Bordet¹, F. Sobas¹, C. Nougier¹, C. Negrier^1,2, S. Le Quellec^1,2
Abstract Number: PO101

Lipid-based Encapsulated Methotrexate Nanoparticles-mediated Low Level Focused Ultrasound Sonoporation Therapy Decrease Inflammation and Restenosis after ArF Excimer Laser Angioplasty of Fibrocalcific Atherosclerosis

H. Mehrad^1,2, A. Foletti^3,2
Abstract Number: OC 03.4

Lipid-binding Antiphospholipid Antibodies Trigger Autoimmune Signaling in Severe COVID-19

A. Hollerbach¹, N. Müller-Calleja¹, D. Pedrosa², M.F. Sprinzl³, P.R. Galle³, L. Teyton⁴, W. Ruf^2,4, K.J. Lackner¹
Abstract Number: PO122

Liver Resection and Perioperative Coagulation Management in Patient with Cirrhosis and HCC – A Case Report

M. Skoko¹, I. Mihic Lasan¹, K. Bilic¹, A. Stefic¹, A. Jularic¹, J. Dodig¹, T. Bosnjak², S. Misir Situm², G. Brozovic², D.V. Vrdoljak², M. Mihaljevic³, T. Vucemilo¹, T. Marinkovic Strumberger¹
Abstract Number: OC 67.4

Liver Safety Case Report from the Phase 3 HOPE-B Gene Therapy Trial in Adults with Hemophilia B

M. Schmidt¹, G.R Foster², M. Coppens³, H. Thomsen¹, D. Cooper⁴, R. Dolmetsch⁴, E.K Sawyer⁴, L. Heijink⁵, S.W Pipe⁶
Abstract Number: OC 77.3

LMWH Prevents Platelet and Extracellular Vesicle Mediated Thrombo-inflammation in Preeclampsia

S. Kohli¹, K. Singh¹, A. Gupta¹, M. Lia², H. Stepan², B. Isermann¹
Abstract Number: PB1195

Location and Burden of Extremity Vein Thrombosis in Patients with Solitary versus Multiple Subsegmental Pulmonary Emboli

R. Meverden¹, Y. Hirao-Try¹, D. Vlazny¹, A. Casanegra¹, D. Houghton¹, D. Hodge², L. Peterson¹, R. McBane¹, W. Wysokinski¹
Abstract Number: PO181

Long Term Recurrence of Venous Thromboembolism: A Retrospective Case-control Study

G. Turatti¹, L. Spiezia¹, M. Marobin¹, A. Poretto¹, E. Borella¹, C. Simion¹, P. Simioni¹
Abstract Number: PB0744

Long Term Trends of Coagulation Parameters in People Living with HIV-1 Treated with Combined Antiretroviral Therapy

S. Bhoelan¹, J. Borjas Howard¹, V. Tichelaar^1,2, W. Bierman³, K. Meijer¹
Abstract Number: OC 07.3

Long-term Joint Outcomes in Hemophilia through Ultrasound: 2-year Interim Results from the Prospective J-DaUPHIN Study

A. Nagao¹, H. Takedani², S. Orita¹, K. Fukutake^1,3, T. Suzuki¹
Abstract Number: PB0019

Long-term Outcome of Percutaneous or Surgical revascularization with and without Prior Stroke in patients with Three-vessel Disease

N. Xu¹, L. Jiang¹, C. Zhang¹, J. Xu¹, R. Liu¹, Y. Zhang¹, X. Zhao¹, R. Gao¹, L. Song¹, J. Yuan¹
Abstract Number: OC 08.2

Long-term Outcomes in Adolescents with Moderate or Severe Hemophilia A: A PedNet Study

D.E. Schmidt¹, A. Michalopoulou², K. Fischer³, J. Motwani⁴, N. Gretenkort Andersson^5,6, H. Pergantou², S. Ranta¹, for the PedNet Study Group
Abstract Number: PB0535

Long-term Prophylaxis with Simoctocog Alfa in Children

A. Klukowska¹, M. Jansen², S. Knaub³, R.J. Liesner⁴
Abstract Number: PB1237

Long-term Risk of Recurrent Venous Thromboembolism after a First Contraceptive-related Event: Data from REVERSE Cohort Study

D. Aziz^1,2, L. Skeith^3,4, M. Rodger^5,6, E. Sabri¹, M. Righini⁷, M. Kovacs⁸, M. Carrier^1,2, S. Kahn^5,9, P. Wells^1,2, D. Anderson¹⁰, I. Chagnon¹¹, S. Solymoss⁵, M. Crowther¹², R. White¹³, G. Le Gal^1,2
Abstract Number: OC 32.4

Long-term Safety and Efficacy of the Anti-TFPI Monoclonal Antibody Marstacimab in Patients with Severe Haemophilia A or B: Results from a Phase 2 Long-term Treatment Study

J. Mahlangu¹, J.L. Lamas², J.C. Morales², D.R. Malan³, J.G. Teeter⁴, R.J. Charnigo⁵, M. Privette⁵, E. Hwang⁵, S. Arkin⁶
Abstract Number: PB1014

Long-term Severe Platelet Dysfunction as a Form of Presentation of Familial Platelet Disorder with Predisposition to Acute Myeloid Leukemia (FPD/AML), due to a RUNX1 Variant

M. Sousa-Pimenta^1,2, M. Pereira^1,3, C. Lau^4,3, A. Gonçalves^5,3, M. E. Oliveira^5,3, E. Cruz¹, R. Santos^5,3, M. Lima^4,3, S. Morais^1,3
Abstract Number: LPB0140

Long-term Survival after Venous Thromboembolism: A Prospective Cohort Study

H. Nilius¹, T. Mertins¹, R. Boss¹, M. Knuchel¹, E. Blozik², J.A. Kremer Hovinga³, S. Eichinger⁴, M. Nagler^1,3
Abstract Number: PB0514

Longer-term Efficacy and Safety of Concizumab Prophylaxis in Hemophilia A and Hemophilia A/B with Inhibitors: Results from the Main and Extension Parts of Concizumab Phase 2 Trials

J. Astermark¹, P. Angchaisuksiri², G. Benson³, G. Castaman⁴, P. Chowdary⁵, H. Eichler⁶, V. Jiménez-Yuste⁷, K. Kavakli⁸, T. Matsushita⁹, L. Hvitfeldt Poulsen¹⁰, J. Oldenburg¹¹, S. Zupancic Salek¹², A. Shapiro¹³, A.P. Wheeler¹⁴, G. Young¹⁵
Abstract Number: PB0263

Longitudinal Measurement of Whole Blood Viscoelastic Properties throughout the Course of Extracorporeal Membrane Oxygenation in COVID-19 Patients with Severe Acute Respiratory Distress Syndrome

M. Lejeune^1,2, G. Hekimian^1,2, P. Masi¹, G. Lebreton^1,2, J. Chommeloux¹, C. Desnos¹, M. Pineton De Chambrun¹, I. Martin-Toutain¹, A. Nieszkowska¹, N. Bréchot¹, M. Schmidt^1,2, C.-E. Luyt^1,2, P. Leprince^1,2, A. Combes^1,2, C. Frere^1,2
Abstract Number: PB0542

Looking Beyond Fixed-Dose Rurioctocog Alfa Pegol Prophylaxis: Post Hoc Analysis of PK-guided Regimens from the PROPEL Phase 3 Study

C. Escuriola-Ettingshausen¹, M. Escobar², J. Windyga³, B. Zulfikar⁴, S.D. Tangada⁵, W. Engl⁶, I. Honauer⁷, H.-Y. Lee⁷, R. Klamroth⁸
Abstract Number: PB0844

Loss of Diagnostic Utility of D-dimers in Secondary Thrombotic Thrombocytopenic Purpura (TTP) in Patients with Human Immunodeficiency Virus (HIV) Infection

S. Louw¹, A. Mayne¹, E.S. Mayne¹
Abstract Number: OC 29.2

Loss of G6b-B Confines Megakaryocyte Differentiation Potential and Promotes Osteosclerosis in Mice

I.C. Becker^1,2,3, G. Manukjan², Z. Nagy^2,1, M. Haffner-Luntzer⁴, M. Englert^2,1, T. Heib^2,1, T. Voegtle^2,1, G. Carina^2,1, R. Bharti¹, S. Dietrich¹, K. Mott², J. Heck^2,1, N. Schlegel², T. Heckel¹, D. Stegner^2,1, I. Pleines^2,1, A. Ignatius⁴, H. Schulze², B. Nieswandt^2,1
Abstract Number: OC 10.4

Loss of P2Y1 Receptor Desensitization Does Not Impact in vivo Hemostasis or Thrombosis Despite Increased Platelet Reactivity in vitro

D.S. Paul¹, T. Blatt², S. Murcia², R.H. Lee¹, E.G. Clark¹, R.A. Nicholas³, W. Bergmeier¹
Abstract Number: OC 37.1

Loss of the Rap-GAP, Rasa3 Leads to Severe Thrombocytopenia Primarily due to αIIbβ3 Integrin-dependent Platelet Clearance in the Spleen

R. Lee¹, D. Ghalloussi¹, P. Kramer¹, J. Kenny¹, B. Nieswandt², W. Bergmeier¹
Abstract Number: LPB0081

Low Adhesion and Interaction Forces of Myh9 Mutant Platelets Lead to Impaired Clot Retraction and Unstable Thrombus Formation

J. Baumann¹, L. Sachs², Z. Nagy¹, I. Schoen³, A. Greinacher², O. Otto^4,5, R. Palankar², M. Bender¹.
Abstract Number: PB1214

Low Awareness of Venous Thromboembolism among the General Population: A Call for Increased Public Enlightenment Programs

H. Okoye¹, T. Nwagha¹, E. Ezigbo², O. Nnachi³, O. Obodo⁴, O. Nnachi³, N. Amu⁴, I. Anigbogu¹
Abstract Number: LPB0124

Low Hemoglobin as a Biomarker for Paediatric Sinus Thrombosis

B. Moiz¹, S. Altaf¹, R. Devi Ukrani¹, A. Arif¹, I. Akbar¹, M. Wahhaab Sadiq¹
Abstract Number: PB0248

Low Incidence of Thrombotic Events in Patients with Covid19: A Cohort Study

C. Vazquez¹, M. Vallone¹, F. Chuliber¹, V. Privitera¹, A. Ferraris¹, R. Cantarella¹, M.F. Indo¹, V. Peuchot¹, F.J. Vazquez¹
Abstract Number: PB0839

Low Plasma ADAMTS13 Activity Contributes to Increased Mortality Rate in Hospitalized Patients with Suspected Heparin-induced Thrombocytopenia

M. Chan¹, X.L. Zheng²
Abstract Number: PB0911

Low Temperature Induces von-Willebrand Factor Expression via Increased Early Growth Response 1 Transcriptional Activity in Splenic Sinusoidal Endothelial Cells

K. Horioka^1,2, H. Tanaka³, K. Okaba¹, N. Ishii¹, A. Motomura¹, H. Inoue¹, K. Alkass², H. Druid², D. Yajima¹.
Abstract Number: PB0918

Low VWF Level due to Heterozygous p.P1127S Mutation of VWF: Clinical Phenotype and Biochemical Effects

M. Tardugno¹, M. Sacco², S. Lancellotti², F. Bernardi³, M. Pinotti³, A. Branchini⁴, E. De Candia⁵, L. Di Gennaro², M. Basso², B. Giusti⁶, G. Castaman⁷, R. De Cristofaro¹
Abstract Number: PB0638

Low-dose Prophylaxis in Severe Hemophilia A: A Single-center Study

M. Borhany¹, M. Abid¹, R. Ahmed², A. Jamal², S. Zafar¹, R. Nadeem²
Abstract Number: PB0284

Lupus Anticoagulant and Outcome of COVID-19 Patients

O. Oyedeji¹, R. Laforest¹, S. Philip¹, Z. Otrock¹
Abstract Number: OC 18.2

Lupus Anticoagulant Interference Study on Various ACT Assays

S. Chen¹, E. Paje¹, P. Yu¹, M. Vega², R. Bottenus¹
Abstract Number: PB0192

Lupus Anticoagulant Positivity is Not Associated with Venous Thromboembolism or In-hospital Mortality In COVID-19

N. Gendron¹, M.-A. Dragon-Durey¹, R. Chocron¹, L. Darnige¹, G. Jourdi², A. Philippe¹, J. Hadjadj², J. Duchemin², L. Khider¹, N. Yatim², L. Mauge¹, P. Gaussem¹, C.M. Samama², B. Planquette¹, O. Sanchez¹, J.L. Diehl¹, T. Mirault¹, M. Fontenay², B. Terrier², D.M Smadja¹
Abstract Number: PB0160

Lymphocyte-Platelet Adhesion and Lymphocyte-platelet Clusters in Patients with Coronavirus Infection SARS-COV-2 (COVID-19)

A. Emelyanov¹, A. Emelyanova¹, E. Zaytseva¹, V. Kuchinskaya¹, S. Igumnov¹, J. Igumnova¹, Y. Vitkovsky¹
Abstract Number: PB0990

Lyophilized Human Platelets Interact with Fresh Platelets to Promote Hemostasis Under Shear in vitro

B. Ishler¹, A. Lee¹, S. Torramadé-Moix², S. Samambar², M. Diaz-Ricart², G. Escolar², K. Moskowitz¹
Abstract Number: PB0882

Lyophilized Human Platelets Support Thrombosis Unlike Normal Platelets in the Presence of GPIIb/IIIa Antagonists

M. Dickerson¹, K. Moskowitz¹