ISTH 2022 Congress Archives - ISTH Congress Abstracts

Abstract Number: PO0037

Factor Infusion in Haemophilia in The Morning Increases Profilaxy Efficiency

C. Albayrak¹, D. Albayrak²
Abstract Number: VPB1418

Factor V Leiden polymorphism, prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T polymorphism in recurrent pregnancy loss.

F. Megdich¹, I. Krichen¹, L. Mbarek², I. Ben Ayed², K. Chaabene³, C. Kallel⁴
Abstract Number: VPB0207

Factor VIII K1813A has high affinity for activated factor IX and enhances global coagulation function

Y. Nakajima¹, M. Takeyama², A. Oda³, K. Nogami²
Abstract Number: OC 28.1

Factor X – Protease activated receptor-2 signaling in the regulation of diet-induced obesity

D. Kaur¹, M. Thati¹, W. Ruf²
Abstract Number: OC 74.5

Factor XI and Plasma Kallikrein apple domain structures reveal alternate kininogen bound complexes

J. EMSLEY¹, C. Li¹, A. Bar Barroeta², J. Meijers³
Abstract Number: PB0595

Factor XII activation by NET accumulation aggravates COVID-19-associated pulmonary thrombo-inflammation

H. Englert¹, C. Rangaswamy¹, C. Deppermann², J. Sperhake¹, C. Krisp¹, D. Schreier¹, E. Gordon³, S. Konrath⁴, M. Haddad⁵, G. Pula⁶, R. Mailer⁴, H. Schlüter¹, S. Kluge¹, F. Langer⁷, K. Püschel¹, K. Panousis⁸, E. Stavrou⁹, C. Maas¹⁰, T. Renné⁵, M. Frye¹
Abstract Number: OC 03.1

Factor XII heavy chain structure

J. EMSLEY¹, M. saleem², C. Li¹, H. Philippou³
Abstract Number: OC 24.4

Factor XIII levels correlate with fibrinogen concentrations in patients with venous malformations and chronic disseminated intravascular coagulopathy

N. Fordham¹, J. Clark¹, A. Taylor¹, K. Sibson¹, L. Solman¹, M. Glover¹, M. Mathias²
Abstract Number: PB0446

Factors Associated with Anticoagulant Treatment Initiation Among Venous Thromboembolism Patients with Cancer

S. Shah¹, A. Dhamane², M. Ferri², R. Bruette¹, V. Noxon¹, X. Liu², J. Jiang², X. Luo³
Abstract Number: VPB0467

Factors influencing the decision making on thrombolytic therapy in normotensive patients with pulmonary embolism: data from SIRENA registry

N. Cherepanova¹, I. Mullova¹, T. Pavlova², A. Erlikh³, O. Barbarash⁴, S. Berns⁵, E. Schmidt⁵, D. Duplyakov⁶
Abstract Number: OC 65.5

Factors influencing anti-Xa assays in different groups of critically ill and non-critically ill patients receiving unfractionated heparin: a multicenter prospective study

D. Lasne¹, M. Toussaint-Hacquard², C. Delassasseigne³, A. Bauters⁴, C. Flaujac⁵, P. Savard⁶, C. Mouton³, E. De Maistre⁷, A. STEPANIAN⁸, J. Georges⁹, A. Gros⁹, A. Mansour¹⁰, G. Leroy¹¹, R. Jouffroy¹, M. Mattei², A. PONTIS¹², M. NEUWIRTH¹³, E. Curis¹⁴, V. Siguret¹⁵, I. Gouin¹²
Abstract Number: PB1200

Factors Influencing Health-related Quality of Life in Patients with Immune Thrombocytopenia

C. Ittikamonchok¹, S. Kaewsuwan², P. Jewprasertpan², T. Wilailak², K. Sophonwatanagit², P. Niprapan³, N. Hantrakun³, C. Chai-Adisaksopha³
Abstract Number: OC 04.2

Factors influencing time from initial presentation to start of plasma exchange in patients with acute thrombotic thrombocytopenic purpura in the United Kingdom

T. Bull¹, R. McCulloch², A. Doyle³, P. Nicolson⁴, R. Shaw⁵, Z. Sayar⁶, A. Langridge⁷, M. Pettitt⁸, R. Perry⁸, D. Tucker⁹, M. Scully¹⁰
Abstract Number: PB0416

Falsely elevated PT-INR results measured with Quick point-of-care methods and Quick laboratory method in patients with antiphospholipid syndrome.

A. Kristoffersen¹, T. Lindahl², H. Alvheim³, A. Stavelin³, M. Hellum⁴, U. Ørvim Sølvik⁵, T. Geir⁵, E. Brodin⁶, S. Sandberg⁷, C. Henriksson⁴
Abstract Number: PB0398

Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids

A. Yamaguchi¹, B. Tourdot², S. Perry³, G. Lee⁴, N. Rhoads¹, C. van Hoorebeke³, J. Sorrentino³, J. Yeung², C. Li⁵, C. Freedman³, T. Holman⁶, M. Holinstat⁵
Abstract Number: PB0465

Feasibility Study of Patient Self-Management of Warfarin using the Fearon Algorithm

A. Wilson¹, J. Saunders¹, S. Vazquez¹, A. Jones¹, M. Fearon², P. Wegener³, D. Witt¹
Abstract Number: PB1405

Features of changes in platelet aggregation activity in pregnant women with preeclampsia

B. Kurbanov
Abstract Number: OC 46.1

Fibrin Film Formation is Enhanced by Red Blood Cells and Reduces Platelet Spreading

G. Alkarithi¹, F. Macrae², C. Duval², R. Ariëns³
Abstract Number: PB0321

Fibrin monomers: a new useful tool to monitor argatroban in patients with Heparin-Induced Thrombocytopenia – A single-center retrospective study

E. TOUBOUL¹, M. BOURRIENNE², J. GAY³, C. ACHARD³, A. PERRIER-CORNET⁴, N. Ajzenberg⁵, D. Faille⁶
Abstract Number: PB0732

Fibrin Promotes Glioblastoma Progression via Focal Adhesion Kinase

L. Knowles¹, C. Wolter², R. Ketter³, S. Urbschat³, S. Linsler³, S. Müller³, A. Müller⁴, X. Zhou⁵, B. Qu⁶, E. Hermann⁷, J. Pilch⁸
Abstract Number: OC 29.3

Fibrinogen αC-Connector is Critical for Fibrin Fiber Assembly and Mechanical Strength

A. Daraei¹, T. Dement², H. Belcher², N. Hudson², M. Guthold³
Abstract Number: VPB0996

FiiRST-2; a prospective, randomized study of clotting factor concentrates versus standard massive hemorrhage protocol in severely bleeding trauma patients

L. Da Luz¹, J. Callum², A. Beckett³, H. Peng⁴, P. Engels⁵, N. Parry⁶, H. Tien¹, A. Nathens¹, J. Carroll⁷, D. Grewal⁷, K. Karkouti⁸
Abstract Number: PB0423

Finding the Gap in Pediatric Post-Thrombotic Syndrome

D. Bastas¹, L. Brandão², J. Vincelli³, N. Amiri³, K. Abdul-Samad³, S. Stephens³, L. Avila¹
Abstract Number: VPB1297

Fingerprint of novel circulating microRNAs identify patients with stroke-embolic stroke of undetermined source

C. Eyileten¹, Z. Wicik¹, J. Jarosz-Popek¹, A. Nowak¹, A. Shahzadi², D. Keshwani¹, T. Adem¹, D. Mirowska-Guzel¹, G. Pare³, M. Postula¹, M. Wolska⁴
Abstract Number: VPB0693

First year report of the multicenter prospective cohort study on ischemic events in adult patients with hemophilia (ADVANCE Japan)

A. Nagao¹, Y. Chikasawa², A. Sawada³, T. Kanematsu⁴, N. Yamasaki⁵, H. Takedani⁶, M. Nojima⁶, T. Fujii⁵, N. Suzuki⁴, T. Matsushita⁴, S. Higasa⁷, K. Amano⁸, T. Suzuki⁹
Abstract Number: PB1152

Fitusiran, an Investigational siRNA Therapeutic Targeting Antithrombin: Analysis of Antithrombin Levels and Thrombin Generation from a Phase 3 Study in People with Hemophilia A or B With Inhibitors

S. Rangarajan¹, A. Srivastava², O. Zulfikar³, E. Cockrell⁴, S. Kichou⁵, Z. Qiu⁶, S. Andersson⁷, B. Mei⁷, G. Young⁸
Abstract Number: OC 50.2

Fitusiran, an Investigational siRNA Therapeutic Targeting Antithrombin: Analysis of Antithrombin Levels and Thrombin Generation from a Phase 3 Study in People with Hemophilia A or B Without inhibitors

S. Pipe¹, A. Srivastava², R. Klamroth³, G. Kenet⁴, H. Tran⁵, L. Fetita⁶, Z. Qiu⁷, S. Andersson⁸, B. Mei⁸, S. Rangarajan⁹
Abstract Number: PB0166

Five cases of Acquired Haemophilia A (AHA) following COVID-19 vaccination in Australia

C. Dix¹, B. Reardon², J. Curnow², R. Bird³, S. P'ng⁴, H. Tran⁵
Abstract Number: PB0187

FIX binding to collagen IV generates thrombin via the extrinsic tenase

G. Morrow¹, M. Laffan², N. Curry³
Abstract Number: VPB0904

Flow cytometry test with ADP stimulation for platelet functional activity assessment

E. Ponomarenko¹, A. Ignatova¹, A. Filkova², A. Pisaryuk³, M. Teterina³, I. Meray³, Z. Kobalava³, A. Sveshnikova¹, G. Novichkova², M. Panteleev⁴
Abstract Number: PB1321

Focused on cerebral venous thrombosis

S. Herrero Martin¹, J. Hernández Cristobal², M. Mora Argumanez³
Abstract Number: OC 37.2

Follicular regulatory T cells promote anti-FVIII inhibitor development in hemophilia A mice

W. Jing¹, J. Chen¹, Y. Cai¹, J. Schroeder¹, A. Dent², Q. Shi¹
Abstract Number: PB1203

Fostamatinib for the Treatment of Immune Thrombocytopenia in a Real-World Setting: A Case Series of Five Patients

R. Grantab¹, V. Markovtsov², C. Hsia³
Abstract Number: OC 45.2

Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation

D. Stegner¹, V. Göb², V. Krenzlin³, S. Beck⁴, K. Hemmen⁵, M. Schuhmann⁶, B. Schörg⁷, C. Hackenbroch⁶, F. May⁸, P. Burkard⁹, J. Pinnecker⁵, A. Zernecke⁶, P. Rosenberger¹⁰, A. Greinacher¹¹, B. Pichler⁷, K. Heinze¹², G. Stoll⁶, B. Nieswandt¹³
Abstract Number: VPB0962

Fracture mechanics of human blood clots: fibrinogen concentration is a critical determinant of clot toughness

R. Kadaba Ramanujam¹, K. Garyfallogiannis², T. Yu³, C. Nagaswami⁴, R. Litvinov⁵, J. Weisel⁶, J. L. Bassani², P. K. Purohit², V. Tutwiler⁷
Abstract Number: PB0953

Free protein S antigen represents more reliable assay for protein S deficiency testing compared with protein S activity and should be used as the first and main test in the diagnostic protocol

S. Margetić¹, F. Tomić², I. Vuga²
Abstract Number: PB0880

Freeze Dried Platelet Derivatives (Thrombosomes®) Retain Hemostatic Properties During Heparin Complexation with Protamine

K. Moskowitz, S. Xu
Abstract Number: PB0541

Freeze-dried plasma development and assessment of biochemical quality

A. Heger¹, M. Karlovits¹, A. Hinz², G. Bengtsson², R. Moezzifard², G. Gruber¹
Abstract Number: VPB1167

Frequency and Quantification of Inhibitors in Congenital Coagulation Disorder Patients – An Experience at Tertiary Care Paediatric Hospital.

n. mazhar¹, j. fatima¹, s. rafi², s. farhan³, n. ahmed⁴
Abstract Number: VPB1346

Frequency and risk factors associated with thromboembolic events in a Sickle Cell Disease cohort

D. Werneck Rodrigues¹, L. Fonseca², S. Souza³, T. Espósito², N. Magalhães³, A. Santos², R. Almeida⁴, J. Almeida¹, M. Thomaz¹
Abstract Number: PB0733

Frequency of Factor II, Factor V Leiden and MTHFR mutations in children with cancer

J. Roganovic
Abstract Number: PB1229

Frequency of reported thrombotic adverse events and clinical outcomes associated with three COVID-19 vaccines

M. Tobaiqy¹, K. MacLure², H. Elkout³, D. Stewart⁴
Abstract Number: PB0832

Frequency of VWF single nucleotide variants in a single institution of Argentina.

A. Woods¹, J. Paiva², M. Casinelli², M. Alberto³, A. Sanchez-Luceros⁴
Abstract Number: PB0500

Frequency, reasons and duration of hospitalization in patients with end-stage kidney disease on hemodialysis: Prospective results of VIVALDI

D. Steiner¹, C. Ay², A. Beyer², S. Schmaldienst³, R. Klauser-Braun⁴, M. Lorenz⁵, I. Pabinger², M. Säemann⁶, O. Königsbrügge¹
Abstract Number: OC 40.1

FRONTIER1: A Phase 1/2 Dose Escalation Study of a Novel Factor VIIIa Mimetic Bispecific Antibody, Mim8, for Evaluation of Safety, Pharmacokinetics, and Efficacy

P. Chowdary¹, F. Jaime², J. Mahlangu³, C. Eskelund⁴, R. Meldgaard⁴, P. Persson⁴, J. Windyga⁵
Abstract Number: PB0872

Fully automated platelet Differential Interference Contrast image analysis via deep learning.

C. Kempster¹, G. Butler², E. Kuznecova¹, K. Taylor¹, N. Kriek³, G. Little³, M. Sowa³, T. Sage³, L. Johnson³, J. Gibbins⁴, A. Pollitt³
Abstract Number: PB1254

Functional Alterations Involved In Increased Bleeding In Hereditary Hemorrhagic Telangiectasia Mouse Models

C. Egido-Turrion¹, E. Rossi², C. Ollauri-Ibáñez¹, M. Pérez-García³, M. Sevilla¹, J. Bastida⁴, J. González-Porras⁵, A. Rodríguez-Barbero¹, C. Bernabeu⁶, J. Lopez-Novoa¹, M. Pericacho⁷
Abstract Number: PB0742

Functional changes in platelets and coagulation during asexual and sexual parasitemia in a controlled human malaria infection

S. Huang¹, W. van der Heijden², I. Reuling³, J. Wan⁴, Q. Yan⁴, R. de Laat-Kremers⁵, A. Van der Ven², P. de Groot⁴, M. McCall⁶, R. Sauerwein⁶, T. Bousema⁶, M. Roest⁷, M. Ninivaggi⁷, Q. de Mast⁸, B. de Laat¹
Abstract Number: OC 11.2

Functional characterisation of coagulopathy in isolated traumatic brain injury

C. Lindsay¹, J. Ross², H. Tucker², A. Rossetto³, M. Carver², J. Pott⁴, A. Almuwallad⁵, R. Stoner², J. Wohlgemut², R. Davenport², K. Brohi¹
Abstract Number: OC 76.1

Functional characterization and structural modeling of DNA-aptamers targeting activated coagulation Factor XIII

N. Shahidi Hamedani¹, A. Biswas², O. Rudan³, C. Meyring², G. Mayer⁴, J. Oldenburg⁵, J. Müller², B. Pötzsch²
Abstract Number: PB0379

Functional expression of GFP-tagged integrin αIIb in a transgenic (knockin) mouse line

C. Kusch¹, D. Johnson², P. Burkard³, P. Öftering³, D. Stegner⁴, S. Beck⁵, B. Nieswandt⁶
Abstract Number: OC 33.1

Functional studies on the interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia

A. Singh¹, F. Toma², G. Uzun³, T. Wagner⁴, L. Pelzl⁵, J. Zlamal⁶, K. Weich⁵, S. Nowak-Harnau³, U. Rothbauer⁴, K. Althaus⁵, T. Backchoul⁶
Abstract Number: PB0871

Fusogenic liposomes label human platelets without impacting normal platelet function

C. Kempster¹, J. Cull², J. Gibbins³, A. Pollitt²
Abstract Number: OC 62.4

FVIII and D-dimer values at trough and peak concentrations of direct oral anticoagulants: important considerations for using these tests in assissting clinical decision for risk stratification scheme

S. Margetić¹, I. Ćelap², S. Šupraha Goreta³
Abstract Number: PB0197

FVIII stimulation causes a variable response in FVIII-specific third generation chimeric antigen receptor (CAR)-transduced T cells.

S. SCATIGNA¹, S. Schultze-Strasser², C. Königs³, A. Schmidt²
Abstract Number: OC 47.1

FVIII-reactive CD4 T cells isolated from non-hemophilic blood respond to multiple epitopes in the FVIII protein

K. Pratt¹, P. Vir², A. Karim², D. Gunasekera², A. Stering³, K. Lieuw⁴
Abstract Number: PB0184

FVIII-specific Immune Response in Hemophilia A Mice Upon Infection

B. Jurado-Mestre¹, V. Kotov², A. Maione², J. Oldenburg³, C. Kurts², J. Becker-Gotot²
Abstract Number: PB0487

FXIII CONCENTRATE USE IN UNCONTRALABLE BLEEDING AFTER CARDIAC SURGERY– WHAT IS THE ROLE? – A CASE REPORT

S. Teixeira¹, M. Carvalho², I. Machado³, D. Cibele³, L. Gonçalves², C. Koch²