ISTH 2022 Congress Archives - ISTH Congress Abstracts

Abstract Number: OC 58.4

Ibrutinib inhibits BMX-dependent endothelial VCAM-1 expression in vitro and pro-atherosclerotic endothelial activation and platelet adhesion in vivo

T. Kohs¹, S. Olson¹, K. Jordan¹, T. Zheng¹, A. Xie¹, J. Hodovan¹, M. Muller¹, C. McArthur¹, J. Johnson¹, B. Sousa², M. Wallisch³, P. Kievit⁴, J. Aslan¹, J. Seixas², G. Bernardes⁵, M. Hinds¹, J. Lindner¹, O. McCarty⁶, C. Puy¹, J. Shatzel¹
Abstract Number: PB0525

Icodextrin as anti- adherence molecule affects cancer cells attachment to the fibrin deposits on the peritoneum surface

I. aldybiat¹, S. Mirshahi², J. Soria¹, M. Pocard¹, M. Mirshahi³
Abstract Number: OC 65.4

Idarucizumab for Reversal of Dabigatran: Multicenter Real-World Experience

P. Barzallo Burbano¹, C. Fernández Maqueda², M. Meijón³, N. Revilla³, M. Blanco Bañares⁴, B. Fernández⁵, R. Rodríguez González⁶, M. Sola Aparicio⁷, B. Rosado Sierra⁷, S. Asenjo⁸, I. Gutiérrez Jomarrón⁹, P. Pilar Llamas Sillero¹⁰, P. Prieto Martínez², R. De Santiago Álvarez², J. Díez Martín¹¹, G. Pérez Rus¹, C. Pascual Izquierdo¹¹
Abstract Number: VPB1165

IDEAL study: A real-world assessment of pattern of use and clinical outcomes with recombinant factor IX albumin fusion protein (rIX-FP) in patients with haemophilia B in Italy

G. Castaman¹, A. Tagliaferri², A. Molinari³, F. Peyvandi⁴, A. Coppola⁵, A. Finardi⁶, I. Schiavetti⁷, D. Vaccari⁸, A. Rocino⁹
Abstract Number: PB0337

Identification and characterisation of ANKRD26-related thrombocytopenia in patients from the GAPP cohort.

H. Vyas¹, G. Lowe², N. Morgan¹
Abstract Number: VPB1251

Identification and evaluation of novel variants associated with platelet function disorders by NGS-based high-throughput sequencing

H. Schulze¹, A. Borst², E. Klopocki², O. Andres³
Abstract Number: PB1029

Identification and functional characterisation of alternatively spliced novel isoforms of human protein C (PROC) gene

S. Abul Kalam¹, F. Naaz²
Abstract Number: PB1276

Identification of a red cell hemostatic mechanism causing COVID-19 microvascular obstruction

Y. Yuan¹, M. Wu², I. Alwis³, R. Smythe³, J. Maclean³, t. Woodruff⁴, T. Barrett⁵, a. rapkiewicz⁶, J. Shaun⁷
Abstract Number: OC 74.4

Identification of a site on Factor XII required for interactions with polyphosphate and other soluble polyanions

A. Shamanaev¹, M. Litvak², S. Dickeson², D. Gailani³
Abstract Number: OC 68.1

Identification of non-coding genomic regions involved in the aetiology of bleeding, platelet, and thrombotic disorders.

L. Stefanucci¹, M. Sims², J. Lambourne³, F. Burden⁴, L. Grassi⁴, D. Seyres⁵, J. Stephens⁵, R. Tomaz⁵, F. Lugtu⁵, D. Greene⁵, N. Owens⁶, K. Megy⁵, S. Sivapalaratnam⁷, K. Freson⁸, L. Vallier⁵, E. Turro⁹, W. Ouwehand¹⁰, M. Frontini⁶
Abstract Number: PB0390

Identification of novel inhibitors of the platelet collagen receptor GPVI by a phenotypic screening assay

S. Troitiño¹, I. Izquierdo², N. Gómez-Romero², F. Rodríguez Del Río², G. Prieto Da Cuña², L. Hermida-Nogueira¹, E. Domínguez³, M. Loza⁴, Á. García¹
Abstract Number: OC 34.5

Identification of risk factors for major bleeding during anticoagulation and recurrent venous thromboembolism after its discontinuation in patients with a first unprovoked venous thromboembolism.

C. Gabara¹, Y. Yamashita², J. Aibar¹, C. Zamora³, J. Moisés¹, C. FONT¹, R. Valle⁴, A. Bura-Riviere⁵, L. Mazzolai⁶, A. Lorenzo⁷, A. Ballaz⁸, O. Madridano⁹, J. Suriñach¹⁰, J. Fernández-Reyes¹¹, A. Villalobos¹², P. Verhamme¹³, J. López-Sáez¹⁴, A. Gil-Díaz¹⁵, J. Vela¹⁶, M. Monreal¹⁷
Abstract Number: VPB0437

Identifying Clinical Predictors for Thrombus Progression in Cirrhotic Patients with Untreated Splanchnic Vein Thrombosis

H. McMurry¹, J. Sabile¹, B. Elstrott¹, B. Chobrutskiy¹, A. Mohinani², S. Patel¹, S. Gowda¹, J. Shatzel²
Abstract Number: OC 32.1

Identifying novel stabilin-2 plasma ligands using proximity labeling

M. Underwood, K. Golden, K. Desch
Abstract Number: OC 23.5

Identifying phenotypes of deep vein thrombosis and their relation to clinical outcomes beyond recurrence

A. Iding¹, A. Pallares Robles², V. ten Cate³, H. ten Cate⁴, P. Wild³, A. ten Cate-Hoek⁵
Abstract Number: OC 31.5

Identifying which emergency department patients should be tested for pulmonary embolism

D. Christopher¹, K. Grewal², S. Ghazalbash³, F. Mowbray³, M. Zargoush³, K. de Wit⁴
Abstract Number: OC 43.1

Idntification of a von Willebrand factor homozygous deep intronic variant by next-generation analysis, and subsequent validation by mRNA analysis and study of the patient-derived endothelial cells

H. Yadegari¹, M. Jamil², J. Oldenburg³
Abstract Number: VPB0610

IL-2 (T330G) gene promoter polymorphism and its effect on lymphocyte-platelet adhesion in patients with coronavirus infection SARS-COV-2 (COVID-19)

A. Emelyanov, A. Emelyanova, E. Zaytseva, Y. Vitkovsky
Abstract Number: OC 20.4

IL-6 is a Biomarker for Joint Bleeds in Hemophilia

L. Knowles¹, C. Wolter², L. Beyer¹, M. Menger³, M. Laschke³, U. Grün⁴, E. Hermann⁵, J. Pilch⁶
Abstract Number: OC 04.5

Immune Medicated Thrombotic Thrombocytopenic Purpura relapse is associated with HLA-DRB1*15:01

M. Stubbs¹, A. Doyle², C. Cheshire³, A. Levine³, M. Thomas⁴, J. Westwood¹, R. Kleta³, D. Gale³, H. Stanescu³, M. Scully¹
Abstract Number: PB1053

Immunophenotyping and cell sorting of human MKs from human primary sources or differentiated in vitro from hematopoietic progenitors

A. Acebes-Huerta¹, P. Martínez-Botía¹, C. Martín Martín¹, A. Bernardo², A. R. Rodríguez³, M. Vicente-Ayuso⁴, C. Benavente Cuesta⁵, L. Gutiérrez⁶
Abstract Number: PB0309

Immunoprofiles and open ADAMTS13 in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura

K. Sakai¹, M. Matsumoto², L. De Waele³, C. Dekimpe³, C. Tersteeg⁴, S. De Meyer⁴, E. Hamada⁵, M. Kubo², K. Vanhoorelbeke⁴
Abstract Number: PB0660

Impact of a product-specific reference standard for the measurement of a PEGylated rFVIII activity: an ex-vivo study.

L. Bounaix¹, O. Bulla², P. Fontana²
Abstract Number: PB0789

Impact of age on in vitro metabolism of clopidogrel: a potential explanation for high on-treatment platelet reactivity in elderly?

A. PONTIS¹, X. DELAVENNE², M. VERDIER³, S. HODIN⁴, A. ANDRIAMAHARO⁵, P. GUERET⁶, F. NEDELEC-GAC⁶, P. GAUSSEM⁷, C. BACHELOT-LOZA⁸, I. Gouin¹
Abstract Number: VPB0939

Impact of Age-adjusted International Prognostic Index for Predicting Venous Thromboembolism in Thai Patients with Diffuse Large B-cell Lymphoma

N. Hantrakun¹, P. Phinyo², A. Tantiworawit¹, E. Rattaritamrong¹, C. Chai-Adisaksopha¹, T. Rattanathammethee¹, S. Hantrakool¹, P. Piriyakhuntorn¹, T. Punnachet¹, P. Niprapan¹, L. Norasetthada¹
Abstract Number: PB0987

Impact of amotosalen/UVA process for pathogen reduction in platelet concentrates on transfusion efficiency in cardiac surgery

B. Belkacem¹, H. Hamzeh-Cognasse², A. Duchez³, M. Eyraud⁴, C. Arthaud⁴, A. Prier⁵, E. Audoux⁶, T. Ebermeyer⁷, P. Chavarin⁴, A. Kazra¹, J. Morel⁸, J. Palao⁸, F. Cognasse⁶
Abstract Number: PB0381

Impact of Coagulation Factor XI (FXI) on the Binding of Platelet Glycoprotein Ibα to the von Willebrand Factor A1 Domain

M. Nakayama¹, S. Goto², S. Takemoto³, H. Oka², H. Yokota³, S. Takagi⁴
Abstract Number: PB0092

Impact of COVID-19 pandemic on pulmonary embolism incidence and characteristics: a 24 months perspective

p. sterpone¹, M. MERONI², W. Ageno³, M. Donadini⁴
Abstract Number: PB1338

Impact of COVID-19 pandemic on VTE investigation and diagnosis rate in Belfast Health and Social Care Trust, Northern Ireland.

N. Sotiropoulou¹, S. Hannan², G. Benson³, R. Gooding⁴, C. Neill³, C. Corrigan⁴
Abstract Number: PB1154

Impact of emicizumab on anticoagulant drugs at therapeutic concentrations using thrombin generation assay

B. Leroy¹, B. Gillet¹, M. Brionne Francois¹, Y. REPESSE²
Abstract Number: PB0544

Impact of fasting on INR in Ramadan on Muslim population taking warfarin.

A. Jahangir, S. khan, M. Quraishi, A. Taqi
Abstract Number: PB1010

Impact of fresh frozen plasma dosing in patients with a left ventricular assist device undergoing heart transplant

P. Dobesh¹, H. Brink², M. Thorson¹, T. Ruter¹, M. Edwards¹
Abstract Number: VPB1374

Impact of implementation of primary thromboprophylaxis protocol in hospitalized hematologic malignancies patients.

A. López Sacerio¹, M. Tejeda Ramón¹, M. Suárez Rodríguez¹, J. Cruz Rodríguez¹, A. Morales Helguera²
Abstract Number: PB1172

Impact of inhibitors on the procoagulant efficacy of bypass agents or hemostatic factors in combination with emicizumab

E. Arias Salgado¹, A. Dos Santos¹, E. Monzón Manzano¹, P. Acuña¹, M. Alvarez-Román², M. Martín Salces¹, M. Rivas Pollmar³, S. García Barcenilla⁴, N. Butta¹, V. Jiménez Yuste⁵
Abstract Number: PB1288

Impact of periodontal inflammation on the cardiac tissues in a murine model

H. El Itawi¹, F. Batool², C. Stutz², F. Zobairi-El Ghazouani³, O. Huck², F. Toti²
Abstract Number: PB0764

Impact of Puumala Hantavirus infection on primary haemostasis: potential mechanisms of thrombocytopenia

A. Schmuckenschlager¹, A. Assinger², J. Wigren Byström³, A. Fors Connoly³, C. Ahlm³, M. Forsell³, W. Schrottmaier²
Abstract Number: PB0341

Impact of SARS-CoV-2 Vaccination in Thrombotic Thrombocytopenic Purpura Patients

M. Capecchi¹, P. De Leo², M. Biganzoli², I. Mancini³, P. Agosti⁴, B. Ferrari⁵, R. Gualtierotti⁶, A. Artoni⁷, F. Peyvandi⁸
Abstract Number: PB0081

Impact of the COVID-19 pandemic on anticoagulation control for patients using warfarin

L. O'Loughlin¹, S. Shah², C. Hubbard², G. Barnes³, M. Fang², D. Kazi⁴, R. Patell⁴
Abstract Number: PB1062

Impact of the variability between normal pooled plasma batches on normalized ratio and mixing time reference cut-off values in lupus anticoagulant testing

J. Cabo¹, R. Soleimani¹, L. Morimont², J. Baudar³, M. Guldenpfennig⁴, J. Douxfils², F. Mullier⁵
Abstract Number: OC 60.2

Impact of thrombophilia testing on treatment decision and outcome of thromboembolism and pregnancy morbidity: a single center retrospective cohort study

K. Vrotniakaite-Bajerciene¹, T. Tritschler², K. Jalowiec³, H. Broughton³, J. Brodard³, A. Haynes⁴, A. Rovo³, J. Kremer Hovinga⁵, D. Aujesky⁶, A. Angelillo-Scherrer³
Abstract Number: PB1404

Impact of Tissue factor promoter gene polymorphism with Recurrent pregnancy loss in India.

K. Kishor¹, A. Sharma¹, S. Maharana², C. Laha Roy², R. Ranjan¹, R. Kumar¹, M. Mahapatra³, R. Saxena⁴
Abstract Number: PB0429

Impact of venous thromboembolism on physical functioning: Results from a prospective cohort study

D. Steiner¹, S. Nopp², B. Weber³, O. Schlager⁴, K. Janata-Schwatczek⁵, O. Königsbrügge¹, F. Klok⁶, I. Pabinger⁷, C. Ay⁷
Abstract Number: VPB0577

Impacts of antithrombotic agents on cellular physiology in the pancreatic tumoral environment

H. Tran¹, P. Van Dreden², E. Mbemba³, I. Elalamy⁴, G. Gerotziafas⁵
Abstract Number: PB0217

Impacts of Mim8 on routine coagulation assays, on intrinsic pathway coagulation factor assays and on thrombophilia coagulation tests

L. Fauconnier¹, N. Roland¹, A. Carlo², T. Hervé³, F. Depasse², M. Ezban⁴, L. Nicoud¹, N. Martineau¹
Abstract Number: PB0085

Impaired exercise capacity in Post-COVID syndrome: The role of VWF-ADAMTS13 axis

N. Prasannan¹, M. Heightman², T. Hillman², E. Wall², R. Bell², A. Kessler², L. Neave³, A. Doyle⁴, A. Devaraj², D. Singh⁵, H. Dehbi⁶, M. Scully¹
Abstract Number: PB0765

Impaired platelet function caused by Vibrio cholera outer membrane vesicles

W. Schrottmaier¹, A. Pirabe², U. Resch², J. Santol², S. Frühwirth¹, K. Aung³, M. Dongre³, A. Digruber⁴, B. Jilma⁵, A. Kirschner¹, M. Ehling-Schulz⁴, S. Wai³, M. Forsell⁶, A. Assinger¹
Abstract Number: VPB0568

Implementation and scale-uping of Text Messages for primary care patients using Warfarin: a real life study

V. CHAGAS¹, M. Rego Souza-Silva², M. Paiva Domingues³, D. Pereira², L. Sá⁴, M. Almeida², M. Raposo⁵, J. Oliveira⁶, T. Soares², A. Baldoni⁷, M. Marcolino⁸, M. Parreiras Martins²
Abstract Number: PB1260

Importance of Erythrocyte Arginase-1 for Vascular Smooth Muscle Cell NO Signaling and Calcification

R. Gogiraju¹, L. Renner², M. Bochenek³, K. Zifkos⁴, M. Molitor², P. Wenzel⁴, S. Danckwardt³, T. Münzel⁵, K. Schäfer⁴
Abstract Number: OC 50.3

Improved Procoagulant Activity of Hemophilia B Causing Dysfunctional Factor IX Variants with Factor VIII Mimetics

J. Chau¹, A. Sternberg¹, A. Pishko², L. George¹, B. Samelson-Jones¹
Abstract Number: OC 11.3

Improved Survival in Severely Bleeding Trauma Patients Treated with Low-titer Group O Whole Blood Compared to Component Therapy

E. Mihalko*¹, S. Shea², K. Thomas³, M. Huff⁴, D. Scheurer⁵, G. Bochicchio⁶, P. Spinella⁷
Abstract Number: PB0658

Improvement in school absence after factor replacement in students with haemophilia in Upper Assam, India

A. Dutta, T. Dutta, D. Boruah
Abstract Number: PB1150

Improvement in the Musculoskeletal Health and Quality of Life-Outcomes among Patients with Severe Hemophilia A with Inhibitor after 2 years of Personalised Physiotherapy

M. Podolak-Dawidziak¹, J. Zawilski², M. Bober², E. Stefańska-Windyga³, A. Buczma³, M. Biernat⁴
Abstract Number: OC 01.2

Improvements in Health-Related Quality of Life in Adults with Severe or Moderately Severe Hemophilia B After Receiving Etranacogene Dezaparvovec Gene Therapy

R. Itzler¹, J. Miller², R. Robson², P. Monahan³, S. Pipe⁴
Abstract Number: PB0240

Improving Discussion of Menstrual Cycle and Bleeding During Well-Child Visits at a Pediatric Residency Clinic

A. Jackson¹, A. Yamasaki², E. Parker³, A. Close²
Abstract Number: PB0231

Improving the provision of patient information regarding venous thromboembolism prevention at King’s College Hospital NHS Foundation Trust, London

G. Giron¹, E. Gee¹, L. Georgiou²
Abstract Number: VPB0288

Improving Thromboprophylaxis in Children Admitted to a Quaternary Care Children’s Hospital with COVID-19

A. Yan¹, C. Parsons², G. Caplan³, D. Kelly⁴, J. Duzan⁵, E. Drake⁵, R. Kumar⁶
Abstract Number: PB0196

In silico structural analysis of FVIII molecular changes from missense pathogenic variants in non-severe hemophilia A patients displaying FVIII:C discrepancy between one-stage vs chromogenic assays

L. Rossetti¹, B. Ziegler², M. Arias³, R. Sueldo⁴, V. Marchione⁵, P. Radic⁶, M. Abelleyro⁷, A. Baqués⁸, C. De Brasi⁹
Abstract Number: PB0296

In vitro characterization of a novel Arg102 mutation in the metalloprotease domain of ADAMTS13

L. De Waele¹, L. Vermeersch¹, C. Tersteeg², S. De Meyer², K. Pavenski³, K. Vanhoorelbeke²
Abstract Number: VPB0571

In vitro effects of colloidal silica on clotting of plasma with or without coagulation factor deficiencies, heparization, lupus anticoagulant positivity, or high fibrinogen concentration.

A. Kadowaki¹, M. Wakui², Y. Fujimori³, H. Katagiri⁴, M. Murata²
Abstract Number: PB0829

In Vitro Field Study Assessing How Clinical Hemostasis Laboratories Analyze Recombinant and Plasma-Derived von Willebrand Factor Products

P. Turecek¹, R. Ilk², H. Gritsch¹
Abstract Number: PB0816

In vitro investigation of emicizumab efficacy and mode of action in vWD type 2 and 3 samples

M. Locke¹, N. Receveur¹, A. Kiialainen², T. David²
Abstract Number: PB0163

In vitro monitoring of anti-coagulation therapy in whole blood using magnetic nanoparticles and susceptometry

A. Harper¹, A. Santana-Otero², N. Telling¹, D. Ortega³, D. Cabrera¹
Abstract Number: PB0717

In vitro Rescue of a Nonsense Mutation Responsible for Severe Coagulation Factor V Deficiency Using Ribosome Readthrough Agents

A. Todaro¹, M. Ciccone², M. Serino², D. Gemmati², A. Cuneo², T. Hackeng¹, F. Bernardi³, E. Castoldi⁴
Abstract Number: PB0581

In vivo activation of the contact pathway by thrombin in sterile models of DIC in baboons

R. Keashari¹, R. Silasi¹, G. Regmi¹, C. Lupu¹, D. Gailani², O. McCarty³, F. Lupu¹
Abstract Number: OC 02.5

In vivo murine studies demonstrate that neutrophil activation by anti-NAP2 antibodies contributes to vaccine-induced immune thrombocytopenia and thrombosis (VITT)

C. Field¹, H. Kim², M. Kowalska², M. Weitzman², G. Arepally³, D. Cines⁴, L. Rauova², M. Poncz²
Abstract Number: PB0358

In-depth analysis of the effects of unsteady flows on platelet release from suspensions of proplatelet-bearing megakaryocytes

O. Boiron¹, F. Lanza², C. Strassel², Y. KNAPP³
Abstract Number: PB1105

In-vivo mimicking platelet thrombus formation in a microfluidic system (Anysis): Assessment of P2Y12 inhibitors for cardiology patients

S. Shin¹, S. Kim², C. Choi³, J. Piao¹
Abstract Number: VPB0108

Incidence of anti-platelet factor4/polyanionic antibodies, thrombocytopenia, and thrombosis after COVID-19 vaccination with ChAdOx1 nCoV-19 in Thais

K. Boonyawat, T. Phojanasenee, P. Noikongdee, P. Police, P. Chantrathammachart, P. Niparuck, T. Puavilai, A. Phuphuakrat, P. Angchaisuksiri
Abstract Number: PB1326

Incidence of Pregnancy-associated Venous Thromboembolism: Second Nationwide Study

H. Hwang¹, S. Bang², J. Lee³
Abstract Number: VPB0112

Incidence of thrombotic events in a population affected by Covid-19 in a general hospital in Veracruz, Mexico

L. Del Carpio-Orantes¹, S. García-Méndez², J. Sánchez-Díaz³, A. Rosas-Lozano³
Abstract Number: VPB0286

Incidence, Risk Factors, and Outcome of Thrombotic Events in Pediatric Cancer Patients

R. Çeçen¹, D. Kızmazoğlu¹, Ö. Tüfekçi², Ş. Yılmaz², D. İnce¹, N. Olgun¹, H. Ören³
Abstract Number: PB0906

Incidences and Predictors of Venous Thromboembolism and Mortality in Patients Diagnosed with Lung Cancer among Saudi Population: Retrospective Two-Centre Cohort Study.

R. Almesfir¹, N. Alqudaibi², F. Aleidan³
Abstract Number: PB0044

Increased blood viscosity and red blood cell aggregation in patients with COVID-19

C. Nougier¹, E. Nader², C. Boisson³, S. Poutrel⁴, J. CATELLA⁵, F. Martin², J. Charvet², S. Girard⁶, S. Havard-Guibert², M. Martin², H. Rezigue⁷, H. Desmurs-Clavel⁸, C. Renoux⁹, P. Joly⁹, N. Guillot², Y. Bertrand¹⁰, A. Hot¹¹, Y. Dargaud¹², P. Connes⁴
Abstract Number: VPB0617

Increased CD62P Platelet Expression in Deceased COVID-19 Patients

U. Sukorini¹, A. Arjana², T. Triyono³, I. Trisnawati , A. Yun Jufan, N. Rahmi Ananda
Abstract Number: OC 66.4

Increased Endothelial Secretion and Reduced Circulatory Clearance Contribute to Elevated Plasma von Willebrand Factor Levels in Multiple Myeloma

C. Comerford¹, S. Pal Singh Dhami², P. Murphy³, S. Patmore², S. Ward², U. Budde⁴, J. O'Donnell², S. Glavey³, J. Quinn³, J. O'Sullivan⁵
Abstract Number: VPB0420

Increased expression of protein disulfide isomerase A1 on platelet surface in lupus anticoagulant-associated thrombosis

A. Romer¹, N. Samadi², L. Hell¹, C. Ay³, J. Gebhart⁴, I. Pabinger³
Abstract Number: PB0593

Increased Percentage of Extended Aα Chain Fibrinogen (αE) in COVID-19 Patients

J. de Vries¹, C. Visser¹, M. van Ommen², C. Rokx³, E. van Nood³, E. van Gorp⁴, M. Goeijenbier⁵, J. van den Akker⁶, H. Endeman⁶, D. Rijken⁷, M. Kruip⁷, M. Weggeman², J. Koopman², M. de Maat⁸
Abstract Number: PB0857

Increased Platelet Activation and Platelet-Leukocyte Aggregate Formation in Primary Sclerosing Cholangitis

J. Gerwers¹, H. Englert¹, N. Wolska², F. Glaser², J. Hartl², I. Schregel², M. Sebode², S. Steinmann², J. Weltzsch², C. Weiler-Normann², C. Schramm³, T. Renné⁴, C. Deppermann⁵
Abstract Number: PB1228

Increased platelet aggregation in patients with decompensated cirrhosis indicates higher risk of further decompensation and death.

E. Campello¹, A. Zanetto², C. Bulato², S. Gavasso², F. Farinati², F. Russo², D. Tormene³, P. Burra², M. Senzolo⁴, P. Simioni⁵
Abstract Number: PB0383

Increased platelet procoagulant activity driven by fibrin-GPVI interaction alters clot structure

J. Sandrin Gauer¹, C. Duval², R. Xu³, F. Macrae², C. Tiede², D. Tomlinson², S. Watson⁴, R. Ariëns⁵
Abstract Number: OC 16.3

Increased Rate and Risk Factors of Venous Thromboembolism (VTE) in Older Patients (pts) with Melanoma Receiving Chemotherapy and/or Immune Checkpoint Inhibitors (ICI): a SEER-Medicare Analysis

T. Sussman¹, L. Vu², S. Markt², S. Koroukian², A. Khorana³
Abstract Number: PB0035

Increased thrombus formation via procoagulant platelets in vaccine induced thrombotic thrombocytopenia (VITT)

K. Althaus¹, A. Singh², L. Pelzl¹, J. Zlamal³, I. Marini⁴, T. Backchoul³
Abstract Number: OC 27.3

Individualized target trough FVIII level and optimized prophylaxis in pediatric patients with hemophilia A

K. Huang¹, D. Ai², Y. Zhen², G. Li², Z. Chen², R. Wu³
Abstract Number: OC 19.4

Induction of myeloid cell hypercoagulability is a maladaptive consequence of trained immunity

A. Rehill¹, S. McCluskey², G. Leon², A. Curtis³, C. McMahon⁴, H. Charles-Messance⁵, F. Sheedy⁶, R. Preston²
Abstract Number: PB0456

Inferior vena cava filter in a tertiary Hospital of Barcelona: a descriptive study of 185 cases.

M. Montoya¹, C. Gabara², N. López², A. Morancho², J. Moisés², C. FONT², S. Jiménez², F. Zarco², M. Burrel², P. Bermúdez², E. Serrano², J. Aibar²
Abstract Number: PB0590

Inflammatory convalescent plasma to treat COVID-19: impact of amotosalen/UVA Pathogen Reduction Technology

F. Cognasse¹, H. Hamzeh-Cognasse², A. Duchez³, M. Eyraud⁴, C. Arthaud⁴, A. Prier⁵, E. Audoux¹, O. Hequet⁴, B. Bonneaudeau⁶, S. Rochette-Eribon⁴, F. Teyssier⁴, V. Barlet-Excoffier⁴, P. Chavarin⁴, D. Legrand⁴, P. Richard⁶, P. Morel⁶, P. Tiberghien⁶
Abstract Number: PB0589

Inflammatory markers and auto-Abs to type I IFNs in COVID-19 Convalescent Plasma

F. Cognasse¹, H. Hamzeh-Cognasse², B. Bonneaudeau³, C. Pierre³, J. Huet³, C. Arthaud⁴, M. Eyraud⁴, A. Prier⁵, O. Hequet⁴, A. Fillet³, P. Chavarin⁴, D. Legrand⁴, P. Richard³, F. Pirenne³, J. Casanova⁶, S. Susen⁷, P. Morel³, K. Lacombe⁸, P. Bastard⁶, P. Tiberghien³
Abstract Number: PB1269

Inflammatory stimuli reveal a differential glycocalyx response between venous and arterial endothelial cells

A. Milusev¹, R. Rieben², N. Sorvillo²
Abstract Number: PB0625

Influence of centrifugation and residual platelet count on PAI-1 plasma level, euglobulin clot lysis time and global fibrinolytic capacity of plasma

M. Bareille¹, T. LECOMPTE², F. Mullier³
Abstract Number: PB0059

Influence of complement system genomic variations on the course of COVID-19

J. Gumulec¹, J. Máca², J. Sagan³, J. Škarda⁴, M. Kutěj⁵, N. Chobolova⁶, D. Kaspřák⁷
Abstract Number: PB1074

Influence of hemolysis, icterus and lipemia on Owren PT measured with a viscosity based detection coagulometer

M. Held¹, A. Hillarp², A. Ståhlberg¹
Abstract Number: VPB1278

Influence of titanium dioxide particles on redox processes in human erythrocytes in vitro

A. Skarabahatava¹, M. Sadaunichuk¹, E. Venskaya¹, N. Aliakhnovich²
Abstract Number: PB1240

Inherited Platelet Disorders Associated With Platelet Membrane Glycoproteins Abnormalities: A Portuguese Centre Experience

P. Martinho¹, C. Pinto², J. Cabral³, J. Azevedo², A. Roque², O. Lavrukhina⁴, C. Catarino⁵, F. Rodrigues⁶, E. Antunes⁷, S. Batalha⁸, S. Nobre Fernandes⁹, M. Lopes¹⁰, C. Geraldes¹¹, T. Fidalgo¹²
Abstract Number: PB1412

Inherited thrombophilia and non-O blood type associated with recurrent spontaneous abortion.

L. Spiezia¹, A. Poretto², E. Borella³, G. Turatti³, M. Marobin³, C. Simion³, E. Campello⁴, D. Tormene⁵, P. Simioni⁶
Abstract Number: PB0879

Inhibition of apoptosis during cold storage of platelet concentrates better maintains both platelet functionality and survival

I. Marini¹, Y. Tamamushi¹, C. Maettler¹, L. Pelzl², K. Althaus², S. Nowak-Harnau³, T. Backchoul⁴
Abstract Number: PB0346

Inhibition of PI3KC2alpha selectively reduces platelet recruitment after vascular injury while preserving thrombus architecture

P. Larsson¹, N. Setiabakti¹, V. Tarlac², A. McGovern³, J. Nunez-Iglesias⁴, K. Tunströmer⁵, J. Hamilton², N. Boknäs⁶
Abstract Number: VPB0023

Inhibition of restenosis after orbital atherectomy of severely calcified artery using combined electrohydraulic low level shock wave therapy and 125I- mediated gamma-intravascular brachytherapy

H. Mehrad
Abstract Number: OC 77.1

Inhibition of the Class II PI 3-kinase, PI3KC2a, prevents thrombosis in hyperlipidaemic mice

N. Setiabakti¹, V. Tarlac², J. Hamilton²
Abstract Number: PB0376

Inhibition of the p75 pan neurotrophic receptor partly mitigates BDNF-induced platelet aggregation

S. Fleury¹, I. Boukhatem², M. Welman¹, É. Maurand³, B. Allen¹, H. Saragovi⁴, M. Lordkipanidzé¹
Abstract Number: OC 22.2

Inhibition of von Willebrand factor through stabilization of the ristocetin-binding site

N. Arce, R. Li
Abstract Number: PB0668

Inhibitor development is associated with decreased quality of life in patients with hemophilia

M. Karimi¹, S. Haghpanah², M. Naderi³, S. Kamalian Fard², H. Tavoosi⁴, S. Parand², N. Javanmardi²
Abstract Number: PB0807

Inhibitors in 3 patients with type 3 von Willebrand disease in a Portuguese Centre – management of bleeding and surgeries

C. Catarino¹, F. Rodrigues², A. Pereira², C. Peixoto³, L. Parusnikova³, J. Pestana⁴, S. Campaniço³, J. Lucas⁵, P. Afonso³
Abstract Number: PB0079

Inhibitory potential of anticoagulant and antiplatelet agents on COVID-19-induced NETs release

J. Oliveira¹, L. Silva¹, G. Damiani¹, A. Santos¹, B. Jacintho¹, C. Vaz¹, G. Mesquita², J. Annichino-Bizzacchi³, B. Mazetto¹, E. de Paula⁴, F. de Andrade Orsi⁵
Abstract Number: OC 01.5

Innate and Adaptive Immune Responses to Adeno-Associated Viral Gene Therapy in the Severe Hemophilia A Dog Model

P. Batty¹, A. Mo², M. Ashrafali³, B. Yates³, A. Gonzalez³, B. Handyside³, L. Harpell², D. Hurlbut², A. Menard⁴, A. Pender², L. Razon³, C. Sihn³, A. Winterborn², S. Fong³, D. Lillicrap⁵
Abstract Number: OC 56.5

Insight into genetic predisposition to high plasma levels of Factor VIII (FVIII) and von Willebrand Factor (vWF) in a family with venous thrombosis.

S. Spena¹, A. Cairo¹, F. Gianniello¹, E. Pappalardo², M. Mortarino¹, I. Garagiola³, I. Martinelli¹, F. Peyvandi⁴
Abstract Number: PB0413

Insights on Antiphospholipid antibody syndrome metabolomics by NMR

L. Martins¹, M. Honorato², S. Montalvão³, E. Braga¹, L. Silva², E. de Paula⁴, F. Orsi², L. Tasic¹, J. Annichino-Bizzacchi²
Abstract Number: PB0507

Insulin resistance links to procoagulant clot properties in young adult with type 1 diabetes: a cross-sectional observation study

N. Kietsiriroje¹, S. Pearson², R. Sagar², R. Ariëns³, R. Ajjan²
Abstract Number: PB1248

Integrated diagnostic workflow in two siblings with albinism and suspected Hermansky-Pudlak syndrome

V. Palma-Barqueros¹, N. Fernández-Mosteririn², C. Zaninetti³, N. Pardiñas- Barón⁴, A. Zamora-Canovas⁵, A. Sánchez-Fuentes⁶, N. Revilla⁷, A. Rodríguez-Alen⁸, A. Marin-Quilez⁹, L. Díaz-Ajenjo¹⁰, A. Torrecillas⁶, N. Bohdan⁶, J. Padilla¹¹, C. Miguel-García⁹, V. Vicente¹², M. Lozano¹², A. Greinacher¹³, J. Bastida¹⁴, J. Rivera¹⁵
Abstract Number: OC 63.2

Inter-individual FVIII clearance heterogeneity in PWH in the iPATH study – biological determinants and clinical importance.

E. Elsheikh¹, M. Lavin², N. Larkin³, N. O'Connell³, K. Ryan⁴, M. Byrne⁵, E. Singleton⁴, P. Fallon⁶, J. Johnsen⁷, S. Pipe⁸, P. Turecek⁹, J. O'Donnell¹⁰
Abstract Number: PB1360

Inter-rater reliability of the UK Department of Health VTE risk assessment tool for medical and surgical hospital admissions

D. Horner¹, B. Daniels², M. Holland³, S. Goodacre⁴, B. Hunt⁵, K. de Wit⁶
Abstract Number: PB0739

Interaction of Antiplatelet and Anticoagulant APAC with Complement Proteins Attenuates Complement Activation via C1q and Factor H

J. Kotimaa¹, M. Rezola¹, A. Jouppila², S. Meri¹, R. Lassila³
Abstract Number: PB0534

Interference of PLX038 (pegylated topoisomerase inhibitor SN-38) with coagulation assays

P. Alcedo Andrade¹, P. Desai², S. Nichols², K. Nghiem³, N. Patel³, A. Dulau-Florea³, C. Pleyer⁴, A. Thomas², C. Bolan⁴, R. Pruthi⁵, S. Kalsi⁶
Abstract Number: PB0339

Interference with dendritic cells by siRNA-CD83 can reverse the polarization of Th1/Th2 and Treg/Th17 in ITP patients

X. Wang
Abstract Number: PB0143

Interferences in the dosage of D-dimer and variation between methodologies.

S. Lopes¹, R. Penteado², J. Guerra², T. Costa², E. Welter², V. de Aranda², A. Villarinho², B. Fogo², A. dos Santos², E. da Silveira², D. Yamada², C. Ito², N. Constantino², C. Mendes²
Abstract Number: PB1153

Interim Analysis from B-MORE, a 24-month Prospective, Multicentre, Non-interventional Study on Effectiveness and Usage of Recombinant Factor IX Fc (rFIXFc) in Haemophilia B

H. Glosli¹, S. Ranta², D. Allsup³, I. Ricca⁴, M. Saleh⁵, Å. Carlsheimer⁶, A. Falk⁶, E. Santagostino⁷
Abstract Number: VPB0616

Interleukins that are mostly affected in severe coronavirus disease 2019 (COVID-19)

M. Meiring¹, V. Nkuna¹, L. Botes², F. Smit¹
Abstract Number: LB 02.1

Intermediate versus low-dose low-molecular-weight heparin in pregnant and postpartum women with a history of venous thromboembolism (Highlow Study)

I. Bistervels¹, A. Buchmuller², H. Wiegers³, F. Ní Áinle⁴, B. Tardy⁵, J. Donnelly⁶, P. Verhamme⁷, A. Jacobsen⁸, A. Hansen⁹, M. Rodger¹⁰, M. DeSancho¹¹, R. Shmakov¹², N. van Es³, M. Prins¹³, C. Chauleur¹⁴, S. Middeldorp¹⁵
Abstract Number: PB1065

Interpretation of Coagulation Mixing Study Results in the Era of Direct Oral Anticoagulants

J. Chen¹, M. Losos²
Abstract Number: PB1300

Intestinal Epithelial Protease-Activated Receptor-1 affects Gastrointestinal Motility and the Enteric Nervous System

G. Pontarollo, O. Dremova, V. Nguyen, K. Endres, C. Reinhardt
Abstract Number: PB1137

Intracranial Haemorrhage in Children with Haemophilia in Turkey

M. Sezgin Evim¹, C. Albayrak², E. Zengin³, E. Yılmaz⁴, N. Özdemir⁵, M. Ertekin⁶, G. Özdemir⁷, A. Bahadır⁸, B. Yılmaz⁷, S. Akbayram⁹, F. Küpesiz¹⁰, H. Tokgöz¹¹, B. Tatlı Güneş⁶, Y. Aral¹², C. Acıpayam¹³, F. Belen Apak¹⁴, A. UNUVAR¹⁵, S. KARAMAN¹⁶, H. Ören¹⁷
Abstract Number: PB0980

Intravenous Ferric Gluconate Use in Anemic Heart Failure Patients at a Large Academic Medical Center

S. Coriolan, C. Merchan, A. Katz, T. Ahuja
Abstract Number: OC 57.2

Inversed platelet/fibrin ratio in shear-dependent thrombus formation between patients with COVID-19 and sepsis identifies subtherapeutic GPIIb/IIIa blockade as a potential therapeutic target

L. Weiss¹, M. Drayss², M. Zeitlhöfler³, K. Mott¹, S. Frantz⁴, B. Nieswandt⁵, D. Weismann⁴, H. Schulze⁶
Abstract Number: PB0090

Investigating Levels of Inflammatory Biomarkers Between SARS-CoV-2 Vaccinated and Unvaccinated Subjects

N. Jabeen¹, A. Amanullah², M. Hussain², B. Kantarcioglu³, F. Siddiqui³, J. Fareed³
Abstract Number: OC 75.4

Investigating the health and function of murine platelets generated using a new ex-vivo lung system

N. Tarassova, X. Zhao, A. Poole
Abstract Number: PB0540

Investigation of GGCX interaction with VKD proteins

F. Forin¹, S. Ghosh¹, J. Müller², J. Oldenburg³, A. Biswas², K. Czogalla¹
Abstract Number: PB1280

Investigation of Podoplanin Signalling Complexes in Primary Lymphatic Endothelial Cells

T. AL THUNAYAN¹, M. Tomlinson²
Abstract Number: VPB0228

Investigation of properties of macropore silica sorbents and active dyes as ligands suitable for purification of factor VIII coagulation

N. Shurko, T. Danysh, I. Yurchyshak, S. Miliashkevych, V. Novak
Abstract Number: PB0533

Investigation of the epidemiology of inherited deficiency of coagulation factors in patients attending the Royal Hospital, Muscat, Oman

R. Al Ghaithi, S. Al Hashami, N. Al Amri, S. AL Shiyadi, S. Al Lamki, M. Al Yahyai, M. Al Riyami, M. Al Musalhi, I. Al Salmi
Abstract Number: PB1024

Investigation of thrombin generation assay to assess vaso-occlusive crisis in sickle cell disease

G. Feugray¹, F. Kasonga², M. Grall³, Y. Benhamou⁴, V. Le Cam Duchez⁵, A. Lahary⁶, P. Billoir⁷
Abstract Number: PB0597

Investigation of thrombin generation in COVID-19 patients by a care setting design

G. Tiscia¹, A. De Laurenzo¹, F. Cappucci¹, L. Fischetti¹, G. Favuzzi¹, D. Colaizzo¹, E. Chinni², E. Grandone³
Abstract Number: PB0529

Investigations of the impact of different bleeding disorders using a humanized in vivo mouse model

L. Pelzl¹, A. Singh², I. Marini³, K. Althaus¹, T. Backchoul⁴
Abstract Number: OC 73.5

Investigations to assess Impact of Syk-inhibition on antibody-mediated desialylation: novel implications on therapy for immune thrombocytopenia

A. Singh¹, F. Toma², K. Althaus³, T. Backchoul⁴
Abstract Number: PB0584

Involvement of The Contact Pathway in COVID-19 Coagulopathy

M. Capecchi¹, C. Novembrino², M. Abbattista³, M. Boscolo³, S. Griffini³, E. Grovetti³, A. Artoni⁴, L. Valenti⁵, D. Prati⁶, G. Grasselli⁷, F. Blasi⁸, M. Cugno³, F. Peyvandi⁹
Abstract Number: VPB0394

iPSC-Derived Megakaryocytes as a Model to Study Human Platelet Integrin IIb3 Function

K. Fong¹, O. Kim², A. Gagne³, C. Jobaliya³, J. Maguire³, M. Poncz⁴, D. French³, R. Litvinov⁵, J. Weisel⁶, W. Degrado⁷, L. Brass¹
Abstract Number: PB1391

Iron deficiency in pregnancy is highly prevalent despite suboptimal screening: A population-based cohort study

A. Alam, V. Jain, P. Kaul, S. Lapner, C. Wu, H. Sun
Abstract Number: PO0019

Iron deficiency reduces mitochondrial respiration in skeletal muscle

K. Cabolis¹, T. Richards², K. Smith¹, M. Sajic¹
Abstract Number: VPB0576

Is plasma-derived coagulation factor Xa safe for reversal of direct factor Xa inhibitor?

S. Surov, W. Jankowski, Z. Sauna, M. Ovanesov
Abstract Number: PB1243

ITGB3/ITGA2B-related platelet disorders: phenotypic and genetic aspects of a series of 20 families evaluated in a single centre

C. Monteiro¹, A. Gonçalves², M. Pereira³, M. Gonçalves⁴, C. Lau⁴, E. Cruz⁵, R. Santos⁶, S. Morais⁷
Abstract Number: PB1198

ITP before and after COVID-19 vaccinations: a national cohort study

P. Choi¹, D. Hsu², J. Curnow³, C. TAN⁴, A. Enjeti⁵, H. Tran⁶, V. CHEN⁷, A. Yong⁸, F. Roncolato⁹, J. Simpson¹⁰, D. Pepperell¹¹, R. Bird¹²