ISTH 2022 Congress Archives - ISTH Congress Abstracts

Abstract Number: OC 07.2

Macrophage Galactose Lectin (MGL) is a clearance receptor determining Factor VIII half-life in haemophilia A patients

S. Ward¹, T. Guest*¹, J. O'Sullivan¹, A. Chion¹, J. Fazavana¹, P. Fallon², R. Preston³, J. Johnsen⁴, S. Pipe⁵, P. Turecek⁶, J. O'Donnell⁷
Abstract Number: OC 34.3

Major gastrointestinal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: a score to identify high risk patients

J. CATELLA¹, L. Bertoletti², F. Moustapha³, J. Nieto⁴, R. Valle⁵, j. Pedrajas⁶, A. Villalobos⁷, I. Quere⁸, G. Sarlon⁹, M. Monreal¹⁰
Abstract Number: PB0001

Management of acquired haemophilia A in a Portuguese Center: 16 years and 16 cases

C. Catarino¹, F. Rodrigues², A. Pereira², J. Pestana³, C. Peixoto⁴, S. Campaniço⁴, L. Parusnikova⁴, C. Correia⁴, C. Pereira⁴, E. Parcelas⁵, J. Lucas⁶, D. Passos⁷, S. Croca⁷, P. Afonso⁴, P. Morgado⁷, C. Calisto⁷, S. Cruz⁷, M. Carriço⁷
Abstract Number: PB0847

Management of adult idiopathic thrombocytopenic purpura (ITP) patients with antinuclear antibody (ANA)

M. Borhany¹, S. Zafar¹, M. Abid¹, T. Shamsi²
Abstract Number: PB1411

Management of Antithrombin Deficiency in Pregnancy – 2 cases report

F. Pires¹, A. Freixo², C. Peixoto³, C. Câmara¹, M. Galvão⁴, Á. Beleza⁴
Abstract Number: PB1402

Management of Inherited Antithrombin Deficiency in Pregnancy: The Western Australian Experience

M. Alexander¹, D. Pepperell¹, A. Keegan²
Abstract Number: PB0496

Management of non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation in Spain. RE-BELD study

O. Gavín Sebastian¹, V. Roldan Schilling², V. Barrios³, J. Cosín-Sales⁴, P. Díez-Villanueva⁵, D. Riba⁶
Abstract Number: OC 23.1

Management of Patients with Unprovoked Venous Thromboembolism and a Low Risk of Recurrence with the Vienna Prediction Model: A Prospective Cohort Study

S. Eichinger¹, L. Eischer², H. Sinkovec², P. Gressenberger³, T. Gary⁴, M. Brodmann⁴, G. Heinze², P. Kyrle⁵
Abstract Number: PB1319

Management of superficial venous thrombosis based on individual risk profiles: protocol for the development and validation of three prognostic prediction models in large primary care cohorts

F. van Royen¹, M. van Smeden², C. Moons³, F. Rutten², G. Geersing²
Abstract Number: OC 04.1

Management of thrombotic thrombocytopenic purpura (TTP) without plasma exchange: an update on the Austrian experience

P. Knöbl¹, K. Eller², V. Buxhofer-Ausch³, J. Thaler⁴, K. Gleixner⁵, W. Sperr⁶
Abstract Number: PB1266

Maphosphamide, a cyclophosphamide analog, increases proinflammatory and permeability responses on endothelial cells in vitro

J. Martinez-Sanchez¹, R. Pascual-Diaz², M. Palomo¹, A. Moreno-Castaño³, H. Ventosa², M. Rovira⁴, G. Escolar², E. Carreras¹, M. Diaz-Ricart⁵
Abstract Number: OC 39.3

Mapping hemorrhagic stroke in the fetal and neonatal period as a consequence of thrombocytopenia.

A. Farley, s. Lloyd, M. Dayton, C. Biben, O. Stonehouse, A. Terreaux, S. Taoudi
Abstract Number: VPB1419

Markers of endothelial dysfunction as predictors of recurrent severe preeclampsia

M. Nikolaeva¹, A. Momot², V. Terekhina³, A. Kudinov³
Abstract Number: PB1035

Mathematical modeling suggests the importance of TFPI-mediated inhibition of platelet-surface bound proteins during coagulation under flow

A. Fogelson¹, K. Miyamara², K. Leiderman²
Abstract Number: OC 07.5

Mathematical modeling to identify clotting factor combinations that enhance thrombin generation in hemophilia

M. Stobb¹, K. Leiderman², S. Sindi³, A. Fogelson⁴, K. Neeves⁵, D. Monroe⁶
Abstract Number: VPB0903

Matrix metalloproteinase-13: a novel player of platelet activation and in vivo thrombus formation

S. Momi¹, M. Sebastiano², E. Falcinelli³, P. Gresele³
Abstract Number: PB0073

Matrix metalloproteinases are associated with poor prognosis in hospitalized patients with COVID-19

M. Marcos-Jubilar¹, M. Panizo², A. Alfonso-Piérola¹, J. Orbe³, F. Alegre², A. Argueta², R. Troyas⁴, J. Del Pozo², M. Lozano², J. Páramo², R. Lecumberri²
Abstract Number: PB1101

Measurement of fibrinogen using two concentrations of Thrombin with patients receiving Argatroban or normal plasma spiked with Argatroban: a review of UK NEQAS (Blood Coagulation) exercises 2021.

C. Reilly-Stitt¹, S. Guy², I. Jennings³, S. Kitchen⁴, I. Walker¹
Abstract Number: PB0993

Measurement of procoagulant platelets in platelet-rich plasma by flow cytometer for the diagnosis of heparin-induced thrombocytopenia

L. Pelzl¹, A. Karakuyu², J. Zlamal³, I. Marini⁴, A. Singh⁵, H. Jaffal⁶, S. Hammer⁷, K. Althaus¹, T. Backchoul³
Abstract Number: PB0546

Measurement of β-antithrombin activity in healthy individuals and in patients with different types of antithrombin deficiency

É. Katona¹, R. Gindele², É. Molnár², E. Uj², Z. Bereczky³
Abstract Number: PB0970

Measuring Factor VII Activating Protease (FSAP) in venous thrombosis using a newly developed FSAP generation assay

M. Etscheid¹, K. Hanschmann², P. Sandset³, S. Kanse⁴
Abstract Number: PB1273

Mechanical Injury of a tissue-engineered human arterial construct replicates the thrombotic and pharmacological properties of the native artery.

J. Ranjbar¹, w. Njoroge², J. Roe³, P. Roach⁴, J. Gibbins⁵, Y. Yang², A. Harper⁶
Abstract Number: VPB1301

Mechanism of hepatocyte growth factor-induced decreased expression of protein C inhibitor in HepG2 cells

N. Akita¹, T. Okamoto², J. Nishioka¹, K. Suzuki¹, T. Hayashi³
Abstract Number: PB0931

Mechanisms of cancer associated thrombosis in gynaecological cancer patients-tumour or treatment effect?

M. Ward¹, S. O'Toole², F. Abu Saadeh³, Z. Marchocki⁴, E. Ibrahim⁵, F. Martin⁶, N. Gleeson⁷, J. O'Leary⁸, L. Norris⁹
Abstract Number: VPB0899

Mechanisms of HLA-KO iPSC-platelets immune escape from NK cells

C. Flahou¹, M. Iwasaki², S. Nakamura², N. Sugimoto², K. Eto²
Abstract Number: PB0875

Mechanosensitive Ion Channels Piezo1 in Red Blood Cells are Involved in Platelet-Driven Blood Clot Contraction

R. Litvinov¹, N. Evtugina², R. Giniatullin³, J. Weisel⁴
Abstract Number: PB0448

Median serum trough concentration of apixaban in pulmonary embolism patients after one month of therapy

J. Dzudovic¹, B. Dzudovic², M. Crevar Sakac³, S. Obradovic⁴
Abstract Number: PB0659

Medically Recorded Bleeds and Healthcare Resource Use in the United States Among Adult Males With Hemophilia A

L. Markson¹, L. Young², L. Ban³, Y. Chen¹, P. Fogarty¹
Abstract Number: OC 59.3

Megakaryocyte Engraftment and altered Platelet Function in a Murine Model of Hematopoietic Stem Cell Transplantation

K. Mott¹, C. Keß², A. Frank², S. Hölle³, Z. Nagy², N. Schlegel⁴, M. Eyrich³, H. Schulze⁵
Abstract Number: PB0357

Megakaryocyte-Driven Blood Clot Contraction and its Structural Mechanisms

O. Kim¹, A. Gagne², R. Litvinov³, D. French², L. Brass⁴, J. Weisel¹
Abstract Number: OC 15.4

Menstrual bleeding in adolescents taking dabigatran for acute VTE treatment and secondary prevention

L. Brandão¹, I. Tartakovsky², J. Van Ryn³, C. Miede⁴, M. Albisetti⁵
Abstract Number: VPB0790

Meta-analysis of the frequency of platelet hyperreactivity after antiplatelet treatment in patients with diabetes and hypertension, undergoing percutaneous coronary intervention, 2005–2021

X. Gutierrez Cadavid¹, D. Rúa Molina²
Abstract Number: OC 19.2

Metabolic reprogramming is essential for myeloid cell-dependent haemostatic activity

A. Rehill¹, G. Leon², S. McCluskey², I. Schoen², J. O'Donnell³, A. Curtis⁴, R. Preston²
Abstract Number: PB0305

Method and laboratory specific clinical cut-offs support appropriate interpretation of ADAMTS13 activity assays

S. MacDonald¹, P. Murphy², R. Fretwell³, C. Downey⁴, P. Baker⁵, E. Foxton⁶, C. Lawrence⁷, A. Ali⁸, V. Jenkins⁹, E. Vilar¹⁰, M. Besser¹, E. Symington¹, M. Robinson¹, M. Desborough⁵, W. Thomas¹, J. Yong⁴, T. Dutt⁴
Abstract Number: PB0308

Method Discrepant ADAMTS-13 activity results in first presentation query TTP subjects

T. Pitchford¹, S. Kitchen², J. Vanveen³, R. Maclean³, R. Fretwell³
Abstract Number: PB0982

MGUS-IgA with anti-thrombin activity in a patient with a severe acquired haemorrhagic syndrome.

A. Blanco¹, M. Alberto², M. Romero¹, M. Martinuzzo³, S. Grosso¹, M. Ingratti¹, M. Arias⁴, A. Sanchez-Luceros⁵
Abstract Number: OC 37.3

Mice possess a more limited natural anti-FVIII antibody repertoire than humans that is generated primarily by marginal zone B cells

M. Cormier¹, E. Burnett², C. Hough³, D. Lillicrap⁴
Abstract Number: PB1106

Microfluidic Thromboelastography (Micro-TEG)

S. Shin
Abstract Number: PB0909

Microparticles and D-Dimers improve prediction of chemotherapy- associated thrombosis in cancer patients

M. CHEKKAL¹, N. YAFOUR², M. ELHORRI³, A. SAADI OUSLIM⁴, A. ADDA⁵, N. ZMOULI⁵, M. Bennaoum⁵
Abstract Number: PB0580

Microvesicles from Stored Platelets Promote High Molecular Weight Kininogen Cleavage Leading to Bradykinin Generation.

D. NOUBOUOSSIE¹, M. Henderson¹, A. Ilich², P. Ellsworth¹, M. Karafin¹, R. Pawlinski¹, M. Hoffman³, S. Strickland⁴, D. Monroe¹, N. Key¹
Abstract Number: PB1151

Mild Bleeding Phenotypes in Severe Hemophilia A with Transfusion Dependent Alpha-thalassemia

P. Pongphitcha¹, W. Sasanakul², P. Kadegasem², D. Songdej³, A. Chuansumrit⁴, N. Sirachainan⁵
Abstract Number: PB0223

Mim8 does not affect FVIII function in hemophilia A

J. Lund, K. Jensen, M. Ezban
Abstract Number: OC 50.5

Mim8 is associated with improved thrombin generation vs. emicizumab in patients with haemophilia A, with and without inhibitors

J. Windyga¹, P. Chowdary², F. Jaime³, C. Eskelund⁴, P. Jørgensen⁴, M. Kreilgaard⁴, J. Mahlangu⁵
Abstract Number: VPB1006

Mini-invasive surgical treatment of haemorrhoiadal bleeding in patients with cardiovascular disease under antithrombotic therapy

A. Tsitskarava
Abstract Number: PB0655

Minor surgical procedures and the outcome of immunotolerance induction: an analysis of the BrazIT Study

R. Camelo¹, M. Moreira Dias², L. de Magalhães³, L. Jardim⁴, A. De Oliveira⁵, R. Ribeiro⁶, V. Franco⁷, M. Roberti⁸, F. Callado⁹, L. Etto¹⁰, M. De Cerqueira¹¹, M. Cerqueira¹², C. Lorenzato¹³, I. Pinto¹⁴, É. Serafim¹⁵, A. Garcia¹⁶, T. Anegawa¹⁷, D. Neves¹⁸, D. Tan¹⁹, S. Rezende²⁰
Abstract Number: OC 18.3

MiR-146a seeds a pro-inflammatory state in acute myocardial infarction of young patients promoting recurrence

A. de los Reyes-García¹, J. Rivera Caravaca², S. Aguila Martinez³, N. García-Barberá⁴, L. Zapata-Martínez⁴, M. Lozano⁵, F. Marín², C. Martínez⁴, R. Gonzalez-Conejero Hilla⁴
Abstract Number: OC 49.5

Mitochondrial ATP generation in stimulated platelets is essential for granule secretion but dispensable for aggregation and procoagulant activity

P. Kulkarni¹, M. Ekhlak², V. Sonkar³, D. Dash²
Abstract Number: OC 66.5

Mitochondrial dysfunction in platelets from patients with JAK2 V617F essential thrombocythemia and polycythemia vera underlie thrombo-hemorrhagic complications

O. Esparza¹, B. McMahon², G. Hernandez³, D. Le³, M. Kelher⁴, T. Nemkov⁵, A. D'Alessandro⁵, J. Lopez⁶, P. Davizon-Castillo⁷
Abstract Number: PB0834

Mixed Phenotype 1/2E Von Willebrand Disease in Two Slovak Patients: Case Report

J. Zolkova¹, Z. Kolkova², D. Loderer², J. Sokol³, T. Simurda⁴, A. Stryckova³, M. Dobrotova¹, J. Ivankova⁵, I. Skornova¹, Z. Lasabova⁶, P. Kubisz⁷, J. Stasko⁷
Abstract Number: VPB0349

ML355 modulates platelet activation and prevents ABT-737 induced apoptosis in platelets

V. Shpakova¹, S. Gambaryan², N. Rukoyatkina³
Abstract Number: OC 52.1

Mode of delivery and intracranial hemorrhage in newborns with hemophilia: A Systematic Review and Meta-analysis

N. Radadia¹, D. Vyas², E. Trinari³, A. Chan⁴, J. Petropoulos⁴, M. Bhatt⁵
Abstract Number: PB0511

Model of P2RY12 -T-744C, (GPIbα) – C482T, NOS3 – T-786C, MTHFR – C667T Gene Interactions in Patients with High Cardiovascular Risk

A. Esmaeil, E. Shorikov, D. Shorikova, O. Khukhlina, P. Shorikov
Abstract Number: OC 64.4

Modeling gray platelet syndrome: longitudinal mouse studies and in vitro human iPSC-derived megakaryocytes to investigate clinical and cellular features

J. Collins¹, L. Mayer¹, L. Kollipara², A. Sickmann³, H. Zhou⁴, G. Hoffman⁵, W. Erber⁵, C. Ghevaert¹, W. Ouwehand⁶, J. Guerrero¹
Abstract Number: PB1282

Models for identification of endothelial glycocalyx degradation mechanisms during Puumala virus infection

C. Jacquet¹, M. Bally², C. Ahlm³, A. Fors Connoly³
Abstract Number: PB1158

MOdern Treatment of Inhibitor-PositiVe PATiEnts with Haemophilia A – MOTIVATE (www.motivate-study.com)

R. Sidonio¹, C. Escuriola Ettingshausen²
Abstract Number: OC 24.5

Modest Performance of Available Risk Prediction Models when Used to Predict Hemorrhage in Patients with Chronic Liver Disease

A. Afzal¹, L. Suhong², B. Gage³, K. Sanfilippo⁴
Abstract Number: PB0562

Modifications in the Thrombin Active Site S4 Subpocket Induce Resistance to Direct Thrombin Inhibitors

V. Strijbis¹, K. Cheung², T. Rutten², B. De Bruin², P. Reitsma³, D. Verhoef³, M. Bos⁴
Abstract Number: PB1258

Modulation of monocytes inflammatory and hemostatic phenotype after transcatheter aortic valve replacement and consequences on post-procedural complications

F. Lassalle¹, F. Vincent¹, M. Rosa¹, A. Rauch¹, F. Dumezy², C. Roumier², D. Dombrowicz¹, C. Gheeraert¹, P. Lefebvre¹, B. Staels¹, A. Vincentelli¹, E. Van Belle¹, S. Susen³, A. Dupont¹
Abstract Number: VPB0645

Modulation of plasmin inhibitor activities, using Affimer technology, improves the hypofibrinolytic environment in high vascular risk individuals

B. Alsayejh¹, N. Pechlivani², C. Tiede³, F. Phoenix³, D. Tomlinson³, S. Ponnambalam³, R. Ajjan³
Abstract Number: PB0200

Molecular algorithm for genetic diagnosis of women with hemophilia A in Argentina

B. Ziegler¹, L. Rossetti², M. Abelleyro³, V. Marchione⁴, D. Neme⁵, E. Medina-Acosta⁶, C. De Brasi⁷, P. Radic⁸
Abstract Number: PB1157

Molecular analysis of inherited bleeding disorders in North Indian cohort

R. Sharma¹, M. Jamwal¹, H. Senee¹, C. Hans², D. Bansal³, A. Trehan³, P. Malhotra¹, N. Kumar², J. Ahluwalia⁴, R. Das¹
Abstract Number: OC 76.3

Molecular Basis for the Conformational Selectivity of Thrombomodulin for TAFI or Protein C

M. Boffa¹, J. Ackersviller², H. Marier², R. Moric², H. Khan²
Abstract Number: PB0202

Molecular Characterization Of The F9 Missense Variants

O. Zulfikar¹, S. Genç², M. Ozbil³, B. Koc⁴, V. Okan⁵, K. Kavaklı⁶, B. Antmen⁷, F. Sahin⁸, A. Meral Gunes⁹, Y. Ay¹⁰, C. Albayrak¹¹, E. Unal¹², M. Dagli¹³, E. Berber¹⁴
Abstract Number: PB0362

Molecular insights into the cause and treatment of congenital thrombocytopenia in mice lacking the co-inhibitory receptor G6b-B

A. MAZHARIAN¹, B. Maître², D. Hennequin³, M. Lourenco-Rodrigues⁴, S. Heising⁵, H. De la salle⁶, S. Watson⁷, C. GACHET², Y. Senis⁸
Abstract Number: VPB0408

Molecular mechanisms of apoptosis in platelets and megakaryocytes in pediatric immune thrombocytopenia

F. Franzoso¹, M. Schmuge², C. Gowin², T. Stein²
Abstract Number: PB0554

Molecular, laboratory and clinical characteristics of inherited antithrombin deficiency: a large, single centre cohort study from the United Kingdom.

K. Mayger¹, A. Doyle², M. Mitchell³, R. Wheeler⁴, B. Hunt²
Abstract Number: PB0175

Monitoring emicizumab with global coagulation assays

D. Bertaggia Calderara¹, A. Batista Mesquita Sauvage², F. Gomez², M. Zermatten², A. Aliotta², L. Veuthey², C. Pereira Portela², L. Alberio²
Abstract Number: PB1022

Monitoring hemostasis with Rotational Thromboelastometry (ROTEM) in patients undergoing aortic valve replacement surgery.

A. García¹, S. Sánchez¹, D. Iyu², N. Marín², J. García-Estañ², J. Moraleda¹, F. García¹
Abstract Number: PB0242

Monitoring of hemostasis and heparinization of neonates undergoing cardiac surgery (CS) using viscoelastic testing (VT) and standard laboratory test (SLT).

M. Lopez¹, P. Rossi², T. Vainstein², B. Diaz³, L. Barrera³, M. Martinuzzo⁴
Abstract Number: PB1202

Monitoring the persistence of vaccine-induced immune thrombotic thrombocytopenia (VITT) antibodies and their pathogenicity

C. Lee¹, L. Clarke², T. Brighton³, S. Chunilal⁴, E. Favaloro⁵, D. Donikian³, M. Kondo³, H. Tran⁶, V. CHEN⁷
Abstract Number: VPB1341

Mortality associated with venous thrombosis in Brazil: evidence of inequalities between low/middle- and high-income countries

I. Batista¹, S. Rezende², M. Cherchiglia³, E. de Paula⁴, F. de Andrade Orsi⁵
Abstract Number: PB0145

MRP-4 («Multidrug Resistance Protein-4) PROTEIN EXPRESSION IN PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) UNDER CHRONIC ASPIRIN TREATMENT

E. Schiera¹, M. Curreli¹, V. Cesario¹, F. De Felice², G. Tocci¹, F. Pulcinelli¹
Abstract Number: PB0301

Multi-centre performance evaluation of ADAMTS13 activity quantification using three different measurement technologies

E. Foxton¹, B. Brannan², P. Murphy³, S. MacDonald⁴
Abstract Number: VPB1379

Multi-dimensional instrument assessment of adherence to warfarin therapy: methodological study

M. Sousa Vianna¹, M. Praxedes², I. Afonso Reis¹, A. Silvina Pagano¹, C. Barbosa Ferreira¹, R. Costa Viana¹, D. Vieira Nascimento¹, M. Parreiras Martins¹
Abstract Number: PB0799

Multi-scale modeling of SIPA showing VWF agglomeration and capture of platelets with high shear

D. Ku¹, Z. Lu², C. Bresette³, C. Aidun⁴
Abstract Number: PB1061

Multicentre Performance Evaluation and Reference Range for an Immunoassay for the Quantitative Determination of Factor XIII Antigen on the cobas t 711 Analyser

M. Büchsel¹, J. Creaghan², U. Geisen³, P. Jilma⁴, R. Jones², S. Kitchen⁵, G. Rozsnyai⁶, P. Quehenberger⁷
Abstract Number: PB1060

Multicentre Performance Evaluation and Reference Range for the Quantitative Determination of Factor IX Activity on the cobas t 711 Analyser

M. Büchsel¹, J. Creaghan², U. Geisen³, P. Jilma⁴, R. Jones², S. Kitchen⁵, G. Rozsnyai⁶, P. Quehenberger⁷
Abstract Number: PB1271

Multiparameter analysis of the time-dependent roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

S. Navarro¹, D. Stegner², B. Nieswandt³, M. Kuijpers⁴, J. Heemskerk⁵
Abstract Number: PB0510

Multiple Myeloma (MM) is Associated with an Increased Risk of Arterial Thromboembolic Events (ATE)

K. Sanfilippo¹, S. Luo², A. Leader³, B. Gage⁴
Abstract Number: PB1125

Musculoskeletal health and health-related quality of life in patients switching to emicizumab prophylaxis

S. Arcudi¹, R. Gualtierotti², V. Begnozzi³, A. Ciavarella⁴, G. Nicolò⁵, S. Siboni⁶, E. Biguzzi³, E. Boccalandro³, F. Peyvandi⁷
Abstract Number: PB0032

Myeloperoxidase-DNA Serum Titers and Delayed Cerebral Ischemia in Patients With Aneurysmal Subarachnoid Hemorrhage

V. Spalart¹, P. Hendrix², J. Oertel², S. Hemmer², J. Geisel³, H. Schneider⁴, K. Martinod¹, J. Witsch⁵
Abstract Number: PO0045

Mystery of reversible neonatal toes gangrene : Case Report

M. Atfy