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ISTH 2022 Congress

July 9-13, 2022. London, England, UK.

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  • Abstract Number: OC 07.2

    Macrophage Galactose Lectin (MGL) is a clearance receptor determining Factor VIII half-life in haemophilia A patients

    S. Ward1, T. Guest*1, J. O'Sullivan1, A. Chion1, J. Fazavana1, P. Fallon2, R. Preston3, J. Johnsen4, S. Pipe5, P. Turecek6, J. O'Donnell7

  • Abstract Number: OC 34.3

    Major gastrointestinal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: a score to identify high risk patients

    J. CATELLA1, L. Bertoletti2, F. Moustapha3, J. Nieto4, R. Valle5, j. Pedrajas6, A. Villalobos7, I. Quere8, G. Sarlon9, M. Monreal10

  • Abstract Number: PB0001

    Management of acquired haemophilia A in a Portuguese Center: 16 years and 16 cases

    C. Catarino1, F. Rodrigues2, A. Pereira2, J. Pestana3, C. Peixoto4, S. Campaniço4, L. Parusnikova4, C. Correia4, C. Pereira4, E. Parcelas5, J. Lucas6, D. Passos7, S. Croca7, P. Afonso4, P. Morgado7, C. Calisto7, S. Cruz7, M. Carriço7

  • Abstract Number: PB0847

    Management of adult idiopathic thrombocytopenic purpura (ITP) patients with antinuclear antibody (ANA)

    M. Borhany1, S. Zafar1, M. Abid1, T. Shamsi2

  • Abstract Number: PB1411

    Management of Antithrombin Deficiency in Pregnancy – 2 cases report

    F. Pires1, A. Freixo2, C. Peixoto3, C. Câmara1, M. Galvão4, Á. Beleza4

  • Abstract Number: PB1402

    Management of Inherited Antithrombin Deficiency in Pregnancy: The Western Australian Experience

    M. Alexander1, D. Pepperell1, A. Keegan2

  • Abstract Number: PB0496

    Management of non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation in Spain. RE-BELD study

    O. Gavín Sebastian1, V. Roldan Schilling2, V. Barrios3, J. Cosín-Sales4, P. Díez-Villanueva5, D. Riba6

  • Abstract Number: OC 23.1

    Management of Patients with Unprovoked Venous Thromboembolism and a Low Risk of Recurrence with the Vienna Prediction Model: A Prospective Cohort Study

    S. Eichinger1, L. Eischer2, H. Sinkovec2, P. Gressenberger3, T. Gary4, M. Brodmann4, G. Heinze2, P. Kyrle5

  • Abstract Number: PB1319

    Management of superficial venous thrombosis based on individual risk profiles: protocol for the development and validation of three prognostic prediction models in large primary care cohorts

    F. van Royen1, M. van Smeden2, C. Moons3, F. Rutten2, G. Geersing2

  • Abstract Number: OC 04.1

    Management of thrombotic thrombocytopenic purpura (TTP) without plasma exchange: an update on the Austrian experience

    P. Knöbl1, K. Eller2, V. Buxhofer-Ausch3, J. Thaler4, K. Gleixner5, W. Sperr6

  • Abstract Number: PB1266

    Maphosphamide, a cyclophosphamide analog, increases proinflammatory and permeability responses on endothelial cells in vitro

    J. Martinez-Sanchez1, R. Pascual-Diaz2, M. Palomo1, A. Moreno-Castaño3, H. Ventosa2, M. Rovira4, G. Escolar2, E. Carreras1, M. Diaz-Ricart5

  • Abstract Number: OC 39.3

    Mapping hemorrhagic stroke in the fetal and neonatal period as a consequence of thrombocytopenia.

    A. Farley, s. Lloyd, M. Dayton, C. Biben, O. Stonehouse, A. Terreaux, S. Taoudi

  • Abstract Number: VPB1419

    Markers of endothelial dysfunction as predictors of recurrent severe preeclampsia

    M. Nikolaeva1, A. Momot2, V. Terekhina3, A. Kudinov3

  • Abstract Number: PB1035

    Mathematical modeling suggests the importance of TFPI-mediated inhibition of platelet-surface bound proteins during coagulation under flow

    A. Fogelson1, K. Miyamara2, K. Leiderman2

  • Abstract Number: OC 07.5

    Mathematical modeling to identify clotting factor combinations that enhance thrombin generation in hemophilia

    M. Stobb1, K. Leiderman2, S. Sindi3, A. Fogelson4, K. Neeves5, D. Monroe6

  • Abstract Number: VPB0903

    Matrix metalloproteinase-13: a novel player of platelet activation and in vivo thrombus formation

    S. Momi1, M. Sebastiano2, E. Falcinelli3, P. Gresele3

  • Abstract Number: PB0073

    Matrix metalloproteinases are associated with poor prognosis in hospitalized patients with COVID-19

    M. Marcos-Jubilar1, M. Panizo2, A. Alfonso-Piérola1, J. Orbe3, F. Alegre2, A. Argueta2, R. Troyas4, J. Del Pozo2, M. Lozano2, J. Páramo2, R. Lecumberri2

  • Abstract Number: PB1101

    Measurement of fibrinogen using two concentrations of Thrombin with patients receiving Argatroban or normal plasma spiked with Argatroban: a review of UK NEQAS (Blood Coagulation) exercises 2021.

    C. Reilly-Stitt1, S. Guy2, I. Jennings3, S. Kitchen4, I. Walker1

  • Abstract Number: PB0993

    Measurement of procoagulant platelets in platelet-rich plasma by flow cytometer for the diagnosis of heparin-induced thrombocytopenia

    L. Pelzl1, A. Karakuyu2, J. Zlamal3, I. Marini4, A. Singh5, H. Jaffal6, S. Hammer7, K. Althaus1, T. Backchoul3

  • Abstract Number: PB0546

    Measurement of β-antithrombin activity in healthy individuals and in patients with different types of antithrombin deficiency

    É. Katona1, R. Gindele2, É. Molnár2, E. Uj2, Z. Bereczky3

  • Abstract Number: PB0970

    Measuring Factor VII Activating Protease (FSAP) in venous thrombosis using a newly developed FSAP generation assay

    M. Etscheid1, K. Hanschmann2, P. Sandset3, S. Kanse4

  • Abstract Number: PB1273

    Mechanical Injury of a tissue-engineered human arterial construct replicates the thrombotic and pharmacological properties of the native artery.

    J. Ranjbar1, w. Njoroge2, J. Roe3, P. Roach4, J. Gibbins5, Y. Yang2, A. Harper6

  • Abstract Number: VPB1301

    Mechanism of hepatocyte growth factor-induced decreased expression of protein C inhibitor in HepG2 cells

    N. Akita1, T. Okamoto2, J. Nishioka1, K. Suzuki1, T. Hayashi3

  • Abstract Number: PB0931

    Mechanisms of cancer associated thrombosis in gynaecological cancer patients-tumour or treatment effect?

    M. Ward1, S. O'Toole2, F. Abu Saadeh3, Z. Marchocki4, E. Ibrahim5, F. Martin6, N. Gleeson7, J. O'Leary8, L. Norris9

  • Abstract Number: VPB0899

    Mechanisms of HLA-KO iPSC-platelets immune escape from NK cells

    C. Flahou1, M. Iwasaki2, S. Nakamura2, N. Sugimoto2, K. Eto2

  • Abstract Number: PB0875

    Mechanosensitive Ion Channels Piezo1 in Red Blood Cells are Involved in Platelet-Driven Blood Clot Contraction

    R. Litvinov1, N. Evtugina2, R. Giniatullin3, J. Weisel4

  • Abstract Number: PB0448

    Median serum trough concentration of apixaban in pulmonary embolism patients after one month of therapy

    J. Dzudovic1, B. Dzudovic2, M. Crevar Sakac3, S. Obradovic4

  • Abstract Number: PB0659

    Medically Recorded Bleeds and Healthcare Resource Use in the United States Among Adult Males With Hemophilia A

    L. Markson1, L. Young2, L. Ban3, Y. Chen1, P. Fogarty1

  • Abstract Number: OC 59.3

    Megakaryocyte Engraftment and altered Platelet Function in a Murine Model of Hematopoietic Stem Cell Transplantation

    K. Mott1, C. Keß2, A. Frank2, S. Hölle3, Z. Nagy2, N. Schlegel4, M. Eyrich3, H. Schulze5

  • Abstract Number: PB0357

    Megakaryocyte-Driven Blood Clot Contraction and its Structural Mechanisms

    O. Kim1, A. Gagne2, R. Litvinov3, D. French2, L. Brass4, J. Weisel1

  • Abstract Number: OC 15.4

    Menstrual bleeding in adolescents taking dabigatran for acute VTE treatment and secondary prevention

    L. Brandão1, I. Tartakovsky2, J. Van Ryn3, C. Miede4, M. Albisetti5

  • Abstract Number: VPB0790

    Meta-analysis of the frequency of platelet hyperreactivity after antiplatelet treatment in patients with diabetes and hypertension, undergoing percutaneous coronary intervention, 2005–2021

    X. Gutierrez Cadavid1, D. Rúa Molina2

  • Abstract Number: OC 19.2

    Metabolic reprogramming is essential for myeloid cell-dependent haemostatic activity

    A. Rehill1, G. Leon2, S. McCluskey2, I. Schoen2, J. O'Donnell3, A. Curtis4, R. Preston2

  • Abstract Number: PB0305

    Method and laboratory specific clinical cut-offs support appropriate interpretation of ADAMTS13 activity assays

    S. MacDonald1, P. Murphy2, R. Fretwell3, C. Downey4, P. Baker5, E. Foxton6, C. Lawrence7, A. Ali8, V. Jenkins9, E. Vilar10, M. Besser1, E. Symington1, M. Robinson1, M. Desborough5, W. Thomas1, J. Yong4, T. Dutt4

  • Abstract Number: PB0308

    Method Discrepant ADAMTS-13 activity results in first presentation query TTP subjects

    T. Pitchford1, S. Kitchen2, J. Vanveen3, R. Maclean3, R. Fretwell3

  • Abstract Number: PB0982

    MGUS-IgA with anti-thrombin activity in a patient with a severe acquired haemorrhagic syndrome.

    A. Blanco1, M. Alberto2, M. Romero1, M. Martinuzzo3, S. Grosso1, M. Ingratti1, M. Arias4, A. Sanchez-Luceros5

  • Abstract Number: OC 37.3

    Mice possess a more limited natural anti-FVIII antibody repertoire than humans that is generated primarily by marginal zone B cells

    M. Cormier1, E. Burnett2, C. Hough3, D. Lillicrap4

  • Abstract Number: PB1106

    Microfluidic Thromboelastography (Micro-TEG)

    S. Shin

  • Abstract Number: PB0909

    Microparticles and D-Dimers improve prediction of chemotherapy- associated thrombosis in cancer patients

    M. CHEKKAL1, N. YAFOUR2, M. ELHORRI3, A. SAADI OUSLIM4, A. ADDA5, N. ZMOULI5, M. Bennaoum5

  • Abstract Number: PB0580

    Microvesicles from Stored Platelets Promote High Molecular Weight Kininogen Cleavage Leading to Bradykinin Generation.

    D. NOUBOUOSSIE1, M. Henderson1, A. Ilich2, P. Ellsworth1, M. Karafin1, R. Pawlinski1, M. Hoffman3, S. Strickland4, D. Monroe1, N. Key1

  • Abstract Number: PB1151

    Mild Bleeding Phenotypes in Severe Hemophilia A with Transfusion Dependent Alpha-thalassemia

    P. Pongphitcha1, W. Sasanakul2, P. Kadegasem2, D. Songdej3, A. Chuansumrit4, N. Sirachainan5

  • Abstract Number: PB0223

    Mim8 does not affect FVIII function in hemophilia A

    J. Lund, K. Jensen, M. Ezban

  • Abstract Number: OC 50.5

    Mim8 is associated with improved thrombin generation vs. emicizumab in patients with haemophilia A, with and without inhibitors

    J. Windyga1, P. Chowdary2, F. Jaime3, C. Eskelund4, P. Jørgensen4, M. Kreilgaard4, J. Mahlangu5

  • Abstract Number: VPB1006

    Mini-invasive surgical treatment of haemorrhoiadal bleeding in patients with cardiovascular disease under antithrombotic therapy

    A. Tsitskarava

  • Abstract Number: PB0655

    Minor surgical procedures and the outcome of immunotolerance induction: an analysis of the BrazIT Study

    R. Camelo1, M. Moreira Dias2, L. de Magalhães3, L. Jardim4, A. De Oliveira5, R. Ribeiro6, V. Franco7, M. Roberti8, F. Callado9, L. Etto10, M. De Cerqueira11, M. Cerqueira12, C. Lorenzato13, I. Pinto14, É. Serafim15, A. Garcia16, T. Anegawa17, D. Neves18, D. Tan19, S. Rezende20

  • Abstract Number: OC 18.3

    MiR-146a seeds a pro-inflammatory state in acute myocardial infarction of young patients promoting recurrence

    A. de los Reyes-García1, J. Rivera Caravaca2, S. Aguila Martinez3, N. García-Barberá4, L. Zapata-Martínez4, M. Lozano5, F. Marín2, C. Martínez4, R. Gonzalez-Conejero Hilla4

  • Abstract Number: OC 49.5

    Mitochondrial ATP generation in stimulated platelets is essential for granule secretion but dispensable for aggregation and procoagulant activity

    P. Kulkarni1, M. Ekhlak2, V. Sonkar3, D. Dash2

  • Abstract Number: OC 66.5

    Mitochondrial dysfunction in platelets from patients with JAK2 V617F essential thrombocythemia and polycythemia vera underlie thrombo-hemorrhagic complications

    O. Esparza1, B. McMahon2, G. Hernandez3, D. Le3, M. Kelher4, T. Nemkov5, A. D'Alessandro5, J. Lopez6, P. Davizon-Castillo7

  • Abstract Number: PB0834

    Mixed Phenotype 1/2E Von Willebrand Disease in Two Slovak Patients: Case Report

    J. Zolkova1, Z. Kolkova2, D. Loderer2, J. Sokol3, T. Simurda4, A. Stryckova3, M. Dobrotova1, J. Ivankova5, I. Skornova1, Z. Lasabova6, P. Kubisz7, J. Stasko7

  • Abstract Number: VPB0349

    ML355 modulates platelet activation and prevents ABT-737 induced apoptosis in platelets

    V. Shpakova1, S. Gambaryan2, N. Rukoyatkina3

  • Abstract Number: OC 52.1

    Mode of delivery and intracranial hemorrhage in newborns with hemophilia: A Systematic Review and Meta-analysis

    N. Radadia1, D. Vyas2, E. Trinari3, A. Chan4, J. Petropoulos4, M. Bhatt5

  • Abstract Number: PB0511

    Model of P2RY12 -T-744C, (GPIbα) – C482T, NOS3 – T-786C, MTHFR – C667T Gene Interactions in Patients with High Cardiovascular Risk

    A. Esmaeil, E. Shorikov, D. Shorikova, O. Khukhlina, P. Shorikov

  • Abstract Number: OC 64.4

    Modeling gray platelet syndrome: longitudinal mouse studies and in vitro human iPSC-derived megakaryocytes to investigate clinical and cellular features

    J. Collins1, L. Mayer1, L. Kollipara2, A. Sickmann3, H. Zhou4, G. Hoffman5, W. Erber5, C. Ghevaert1, W. Ouwehand6, J. Guerrero1

  • Abstract Number: PB1282

    Models for identification of endothelial glycocalyx degradation mechanisms during Puumala virus infection

    C. Jacquet1, M. Bally2, C. Ahlm3, A. Fors Connoly3

  • Abstract Number: PB1158

    MOdern Treatment of Inhibitor-PositiVe PATiEnts with Haemophilia A – MOTIVATE (www.motivate-study.com)

    R. Sidonio1, C. Escuriola Ettingshausen2

  • Abstract Number: OC 24.5

    Modest Performance of Available Risk Prediction Models when Used to Predict Hemorrhage in Patients with Chronic Liver Disease

    A. Afzal1, L. Suhong2, B. Gage3, K. Sanfilippo4

  • Abstract Number: PB0562

    Modifications in the Thrombin Active Site S4 Subpocket Induce Resistance to Direct Thrombin Inhibitors

    V. Strijbis1, K. Cheung2, T. Rutten2, B. De Bruin2, P. Reitsma3, D. Verhoef3, M. Bos4

  • Abstract Number: PB1258

    Modulation of monocytes inflammatory and hemostatic phenotype after transcatheter aortic valve replacement and consequences on post-procedural complications

    F. Lassalle1, F. Vincent1, M. Rosa1, A. Rauch1, F. Dumezy2, C. Roumier2, D. Dombrowicz1, C. Gheeraert1, P. Lefebvre1, B. Staels1, A. Vincentelli1, E. Van Belle1, S. Susen3, A. Dupont1

  • Abstract Number: VPB0645

    Modulation of plasmin inhibitor activities, using Affimer technology, improves the hypofibrinolytic environment in high vascular risk individuals

    B. Alsayejh1, N. Pechlivani2, C. Tiede3, F. Phoenix3, D. Tomlinson3, S. Ponnambalam3, R. Ajjan3

  • Abstract Number: PB0200

    Molecular algorithm for genetic diagnosis of women with hemophilia A in Argentina

    B. Ziegler1, L. Rossetti2, M. Abelleyro3, V. Marchione4, D. Neme5, E. Medina-Acosta6, C. De Brasi7, P. Radic8

  • Abstract Number: PB1157

    Molecular analysis of inherited bleeding disorders in North Indian cohort

    R. Sharma1, M. Jamwal1, H. Senee1, C. Hans2, D. Bansal3, A. Trehan3, P. Malhotra1, N. Kumar2, J. Ahluwalia4, R. Das1

  • Abstract Number: OC 76.3

    Molecular Basis for the Conformational Selectivity of Thrombomodulin for TAFI or Protein C

    M. Boffa1, J. Ackersviller2, H. Marier2, R. Moric2, H. Khan2

  • Abstract Number: PB0202

    Molecular Characterization Of The F9 Missense Variants

    O. Zulfikar1, S. Genç2, M. Ozbil3, B. Koc4, V. Okan5, K. Kavaklı6, B. Antmen7, F. Sahin8, A. Meral Gunes9, Y. Ay10, C. Albayrak11, E. Unal12, M. Dagli13, E. Berber14

  • Abstract Number: PB0362

    Molecular insights into the cause and treatment of congenital thrombocytopenia in mice lacking the co-inhibitory receptor G6b-B

    A. MAZHARIAN1, B. Maître2, D. Hennequin3, M. Lourenco-Rodrigues4, S. Heising5, H. De la salle6, S. Watson7, C. GACHET2, Y. Senis8

  • Abstract Number: VPB0408

    Molecular mechanisms of apoptosis in platelets and megakaryocytes in pediatric immune thrombocytopenia

    F. Franzoso1, M. Schmuge2, C. Gowin2, T. Stein2

  • Abstract Number: PB0554

    Molecular, laboratory and clinical characteristics of inherited antithrombin deficiency: a large, single centre cohort study from the United Kingdom.

    K. Mayger1, A. Doyle2, M. Mitchell3, R. Wheeler4, B. Hunt2

  • Abstract Number: PB0175

    Monitoring emicizumab with global coagulation assays

    D. Bertaggia Calderara1, A. Batista Mesquita Sauvage2, F. Gomez2, M. Zermatten2, A. Aliotta2, L. Veuthey2, C. Pereira Portela2, L. Alberio2

  • Abstract Number: PB1022

    Monitoring hemostasis with Rotational Thromboelastometry (ROTEM) in patients undergoing aortic valve replacement surgery.

    A. García1, S. Sánchez1, D. Iyu2, N. Marín2, J. García-Estañ2, J. Moraleda1, F. García1

  • Abstract Number: PB0242

    Monitoring of hemostasis and heparinization of neonates undergoing cardiac surgery (CS) using viscoelastic testing (VT) and standard laboratory test (SLT).

    M. Lopez1, P. Rossi2, T. Vainstein2, B. Diaz3, L. Barrera3, M. Martinuzzo4

  • Abstract Number: PB1202

    Monitoring the persistence of vaccine-induced immune thrombotic thrombocytopenia (VITT) antibodies and their pathogenicity

    C. Lee1, L. Clarke2, T. Brighton3, S. Chunilal4, E. Favaloro5, D. Donikian3, M. Kondo3, H. Tran6, V. CHEN7

  • Abstract Number: VPB1341

    Mortality associated with venous thrombosis in Brazil: evidence of inequalities between low/middle- and high-income countries

    I. Batista1, S. Rezende2, M. Cherchiglia3, E. de Paula4, F. de Andrade Orsi5

  • Abstract Number: PB0145

    MRP-4 («Multidrug Resistance Protein-4) PROTEIN EXPRESSION IN PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) UNDER CHRONIC ASPIRIN TREATMENT

    E. Schiera1, M. Curreli1, V. Cesario1, F. De Felice2, G. Tocci1, F. Pulcinelli1

  • Abstract Number: PB0301

    Multi-centre performance evaluation of ADAMTS13 activity quantification using three different measurement technologies

    E. Foxton1, B. Brannan2, P. Murphy3, S. MacDonald4

  • Abstract Number: VPB1379

    Multi-dimensional instrument assessment of adherence to warfarin therapy: methodological study

    M. Sousa Vianna1, M. Praxedes2, I. Afonso Reis1, A. Silvina Pagano1, C. Barbosa Ferreira1, R. Costa Viana1, D. Vieira Nascimento1, M. Parreiras Martins1

  • Abstract Number: PB0799

    Multi-scale modeling of SIPA showing VWF agglomeration and capture of platelets with high shear

    D. Ku1, Z. Lu2, C. Bresette3, C. Aidun4

  • Abstract Number: PB1061

    Multicentre Performance Evaluation and Reference Range for an Immunoassay for the Quantitative Determination of Factor XIII Antigen on the cobas t 711 Analyser

    M. Büchsel1, J. Creaghan2, U. Geisen3, P. Jilma4, R. Jones2, S. Kitchen5, G. Rozsnyai6, P. Quehenberger7

  • Abstract Number: PB1060

    Multicentre Performance Evaluation and Reference Range for the Quantitative Determination of Factor IX Activity on the cobas t 711 Analyser

    M. Büchsel1, J. Creaghan2, U. Geisen3, P. Jilma4, R. Jones2, S. Kitchen5, G. Rozsnyai6, P. Quehenberger7

  • Abstract Number: PB1271

    Multiparameter analysis of the time-dependent roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

    S. Navarro1, D. Stegner2, B. Nieswandt3, M. Kuijpers4, J. Heemskerk5

  • Abstract Number: PB0510

    Multiple Myeloma (MM) is Associated with an Increased Risk of Arterial Thromboembolic Events (ATE)

    K. Sanfilippo1, S. Luo2, A. Leader3, B. Gage4

  • Abstract Number: PB1125

    Musculoskeletal health and health-related quality of life in patients switching to emicizumab prophylaxis

    S. Arcudi1, R. Gualtierotti2, V. Begnozzi3, A. Ciavarella4, G. Nicolò5, S. Siboni6, E. Biguzzi3, E. Boccalandro3, F. Peyvandi7

  • Abstract Number: PB0032

    Myeloperoxidase-DNA Serum Titers and Delayed Cerebral Ischemia in Patients With Aneurysmal Subarachnoid Hemorrhage

    V. Spalart1, P. Hendrix2, J. Oertel2, S. Hemmer2, J. Geisel3, H. Schneider4, K. Martinod1, J. Witsch5

  • Abstract Number: PO0045

    Mystery of reversible neonatal toes gangrene : Case Report

    M. Atfy

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