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ISTH 2021 Congress

Platelet Disorders, von Willebrand Disease and Thrombotic Microangiopathies » ADAMTS13 and TTP

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  • ISTH 2021 Congress
    • Platelet Disorders, von Willebrand Disease and Thrombotic Microangiopathies
      • ADAMTS13 and TTP

Abstract Number: PO156

A Refractory Thrombotic Thrombocytopenic Purpura Case Complicated by Hepatic Sinusoidal Obstruction Syndrome and Successful Management with Defibrotide

S. Erdem1, M. Mastanzade1, S. Altay-Dadin2, M. Yanasik3, S. Kalayoglu-Besisik1

Abstract Number: OC 53.4

Anti-ADAMTS13 Antibodies in Patients with Hereditary Thrombotic Thrombocytopenic Purpura (hTTP)

S.R. Heeb1,2, M. Schaller1,2, E. Tarasco1,2, J.A. Kremer Hovinga1,2

Abstract Number: OC 66.2

Anti-cysteine/Spacer Autoantibodies that Open the Conformation of ADAMTS13 Are a Common Feature of the Autoimmune Response in Immune-mediated Thrombotic Thrombocytopenic Purpura

L. De Waele1, A. Curie1,2, K. Kangro1,3, E. Tellier4, G. Kaplanski4,5, A. Männik3, C. Tersteeg1, B.S. Joly6, P. Coppo7, A. Veyradier6, S.F. De Meyer1, E. Roose1, K. Vanhoorelbeke1

Abstract Number: PB0838

Caplacizumab Rapidly Inhibits VWF-platelet Interaction: Pharmacodynamic Data from Healthy Volunteers and Patients with aTTP

F. Callewaert1, J. Minkue Mi Edou2, R. de Passos Sousa3

Abstract Number: OC 53.2

Children with Hereditary Thrombotic Thrombocytopenic Purpura (hTTP) Have a High Incidence of Acute Episodes: Data from the International Hereditary TTP Registry (IHTTP Registry)

E. Tarasco1,2, K. Sakai3, S. Al Shanbary4, L. Bütikofer5, Y. El Chazli6, J.N George7, H. Hengartner8, S. Jalal9, P.N Knöbl10, E. Maaß11, S. Milanovich12, S. Perungo13, G. Sinkovits14, M. Steele15, A.S. von Krogh16,17, K. Wyatt18, B. Lämmle1,19, J.A. Kremer Hovinga1,2, other members Steering Committee international hTTP Registry

Abstract Number: PB0850

Delayed Diagnosis of Congenital Thrombotic Thrombocytopenic Purpura Presenting as Recurrent Cryptogenic Strokes

M. Desancho1, M. Beltrami Moreira1

Abstract Number: PB0837

Design of a Phase 3, Randomized, Controlled Study of Prophylactic and On-demand Treatment with Recombinant ADAMTS13 for Patients with Severe Congenital Thrombotic Thrombocytopenic Purpura

N. Jain1, C. Marquez1, L. Martell1

Abstract Number: OC 66.4

Development of an Easy-to-Use ADAMTS13 Conformation Assay Using Fiber Optic Surface Plasmon Resonance Technology

C. Dekimpe1, Q. Bonnez1, E. Roose1, E. Tellier2, G. Kaplanski2, H.B. Feys3,4, C. Tersteeg1, S.F. De Meyer1, K. Vanhoorelbeke1

Abstract Number: LPB0079

Evaluation of the Different Platelet-dependent von Willebrand Factor Activity Assays Capacity to Assess the in vivo Inhibitory Effect of Caplacizumab on the VWF-platelet Interaction

P. Colpani1, L. Baronciani1, C. Novembrino1, I. Mancini2, G. Cozzi1, P. De Leo1, E. Galbiati1, M. Boscarino2, A. Artoni1, F. Peyvandi1,2

Abstract Number: PB0845

Evaluation of the Local Tolerability of Recombinant ADAMTS13 Following Subcutaneous Injection in Rabbits

J. Blank1, J. McNulty1, J. Nunes1

Abstract Number: PB0842

HIV is Not the Trigger for HIV-associated TTP

M. Meiring1, M. Khemisi2.

Abstract Number: OC 66.1

Investigating the Resistance of ADAMTS13 towards Protease Inhibitors

K. Singh1,2, S. Sohrabipour1,2, H. Madarati1,2, T. Sparring1,2, C. Kretz1,2

Abstract Number: PB0844

Loss of Diagnostic Utility of D-dimers in Secondary Thrombotic Thrombocytopenic Purpura (TTP) in Patients with Human Immunodeficiency Virus (HIV) Infection

S. Louw1, A. Mayne1, E.S. Mayne1

Abstract Number: PB0839

Low Plasma ADAMTS13 Activity Contributes to Increased Mortality Rate in Hospitalized Patients with Suspected Heparin-induced Thrombocytopenia

M. Chan1, X.L. Zheng2

Abstract Number: OC 53.1

Major Adverse Cardiovascular Events Are a Major Cause of Morbidity after Recovery from Immune Thrombotic Thrombocytopenic Purpura

M. Brodsky1, S. Selvakumar2, L. Yanek1, S. Hussain1, A. Moliterno1, R. Brodsky1, S. Chaturvedi1

Abstract Number: PB0836

Melanoma Triggers Severe Thrombotic Thrombocytopenic Purpura and Results in a High Mortality Rate in adamt13-/- Zebrafish

L. Zheng1, L. Cao2, X.L. Zheng1

Abstract Number: OC 53.3

Outcomes of Subsequent Pregnancy in Women with a History of Immune Thrombotic Thrombocytopenic Purpura

J. Brown1, S. Hussain2, M. Mazepa3, A. Moliterno2, S. Chaturvedi2

Abstract Number: PB0851

PK/PD Modeling and Simulations Highlight the Importance of the Intravenous Loading Dose and Daily Dosing Regimen with Caplacizumab for Patients with aTTP

T. Sou1, F. Callewaert2, R. de Passos Sousa3, M.L. Sargentini-Maier1

Abstract Number: PB0840

Plasma BioID of ADAMTS13

H. Madarati1, K. Singh1, T. Sparring1, C. Kretz1

Abstract Number: PO161

Refractory Thrombotic Thrombocytopenic Purpura – A Case Report

A. Aribandi1, C. Ranjith1, S. Sushma2, T. Surapaneni2

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