ISTH 2022 Congress

Hemostatic Systems in Cancer, Inflammation and Immunity

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ISTH 2022 Congress
- Hemostatic Systems in Cancer, Inflammation and Immunity

Abstract Number: PB0726

(Factor VIII / Factor V) Ratio as a New Prognostic Marker for Decompensated Liver Cirrhosis

M. El Horri¹, N. Feghoul¹, F. El Horri², I. Khachaa¹, A. Chikh Khelifa³, M. Baghdadi¹, A. Benglia¹, K. Benbouhadi¹, H. Mimene¹, K. Kebir¹, K. Benhalima¹, L. Benmahdi¹, H. BROUK⁴

Abstract Number: PB0777

Adenovirus-based but not mRNA-based vaccines transiently alter platelet count homeostasis in healthy subjects.

L. lombardi¹, N. Scafa², S. Cesaroni¹, R. Marrapodi³, F. Maiorca⁴, R. Cangemi¹, M. Visentini¹, G. Romiti¹, B. Corica¹, F. Pulcinelli³, M. Venneri¹, S. Basili¹, L. Stefanini³

Abstract Number: VPB0746

Alterations in Coagulation Profiles and Bleeding Rates in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome on Prophylactic Anti-Bacterials

C. Allen, S. Gautam, A. Pine, A. Zeidan, A. Lee, R. Shallis

Abstract Number: PB0728

Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro

R. Herranz¹, J. Oto¹, M. Hueso², E. Plana³, F. Cana², A. Fernández-Pardo², S. Bonanad⁴, C. Vera-Donoso⁵, M. Martínez-Sarmiento⁵, P. Medina²

Abstract Number: VPB0759

Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model

T. Shirai¹, T. Sasaki², N. Tsukiji², S. Ohishi², R. Yokomori², K. Takano², K. Suzuki-Inoue³

Abstract Number: PB0743

Cell-free DNA is increased in plasma of immunothrombotically dysregulated patients with periprosthetic joint infection in part due to lower DNaseI activity

R. Herranz¹, J. Oto¹, M. Fuertes², E. Plana³, F. Cana⁴, C. De La Calva², M. Angulo², F. Arguelles², J. Baeza², I. Baixauli², F. Baixauli², J. Amaya², P. Medina⁴

Abstract Number: PB0750

Changes to platelet quality and function in Waldenstrӧm Macroglobulinaemia

S. Brysland¹, D. Talaulikar², E. Gardiner³

Abstract Number: PB0730

Circulating activated protein C levels are reduced in cancer patients, a novel contribution to tumorigenesis?

J. Oto¹, R. Herranz¹, E. Plana², F. Cana³, J. Amaya⁴, C. Vera-Donoso⁵, M. Martínez-Sarmiento⁵, S. Bonanad⁶, P. Medina³

Abstract Number: OC 28.3

Coagulation factor XII induces persistent uPAR-integrin β1 signaling promoting DNA damage and senescence in diabetic kidneys

A. Elwakiel¹, K. Shahzad¹, I. Gadi¹, R. Rana¹, D. Gupta¹, J. Manoharan¹, S. Kohli¹, T. Renné², B. Isermann¹

Abstract Number: OC 28.5

Coagulation FXI regulates endothelial cell barrier function by inducing VE-cadherin proteolysis in an ADAM10-dependent manner

C. Puy¹, K. Jordan¹, N. Nguyen², C. Lorentz³, E. Tucker³, D. Gailani⁴, O. McCarty⁵

Abstract Number: PB0744

Coagulation markers improve the diagnosis of periprosthetic joint infection: involvement of immunothrombosis

J. Oto¹, R. Herranz¹, A. Fernández-Pardo², M. Fuertes³, E. Plana⁴, A. Cañada⁵, F. Cana², C. De La Calva³, M. Angulo³, F. Arguelles³, J. Baeza³, I. Baixauli³, F. Baixauli³, J. Amaya³, P. Medina²

Abstract Number: PB0738

Complement and Haemostasis: Effects of complement inhibitors in a microfluidic bleeding model

M. Golomingi¹, J. Kohler¹, C. Lamers², R. Pouw², E. Hardy³, D. Ricklin², W. Lam³, V. Schroeder¹

Abstract Number: PB0729

Development of a viral vector for hemopexin protein expression for gene therapy in disorders associated with increased levels of free extracellular heme

F. Lima¹, B. Hounkpe¹, C. Peachazepi de Moraes², I. Borba³, F. Costa¹, E. de Paula⁴

Abstract Number: PB0748

Diminished platelet CLEC-2 sensitivity in kaposiform hemangioendothelioma identified with novel CLEC-2 antagonists

A. Martyanov¹, I. Tesakov², O. An¹, A. Ignatova², G. Svidelskaya³, L. Khachatryan³, J. Eble⁴, D. Kalinin⁵, A. Sveshnikova³

Abstract Number: OC 51.1

Direct oral anticoagulants cause placental vascular abnormalities and epigenetic reprogramming in placenta and the offspring

K. Singh¹, A. Gupta¹, R. Younis¹, H. Mai¹, K. Shahzad², B. Isermann², S. Kohli²

Abstract Number: PB0775