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ISTH 2022 Congress

Platelets and Megakaryocytes » Megakaryocytes and Thrombopoiesis

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  • ISTH 2022 Congress
    • Platelets and Megakaryocytes
      • Megakaryocytes and Thrombopoiesis

Abstract Number: OC 75.1

A 3D microvasculature assay reveals novel sub-cellular dynamics of megakaryocyte endothelial barrier interactions, proplatelet formation and release.

N. Asquith1, D. Freire1, S. Shelton2, K. Machlus3, R. Kamm2, J. Italiano4

Abstract Number: OC 26.2

A dose-escalation phase 1 clinical trial of autologous iPSC-derived platelets (iPLAT1)

N. Sugimoto1, J. kanda2, S. Nakamura3, T. Kitano2, S. Shimizu1, A. Shigemasa1, H. Hirai2, M. Minami2, H. Tada2, D. Momose4, K. Koh4, M. Nogawa5, N. Watanabe6, M. Handa6, A. Sawaguchi7, M. Tanaka8, T. Hayashi8, Y. Tani8, A. Takaori-Kondo9, K. Eto3

Abstract Number: OC 10.3

A novel model of RUNX1-haploinsufficient (RUNX1Lo): Human megakaryocytes infused into mice further characterizes this defect and identifies potential therapeutics

K. Lee, H. Ahn, M. Poncz

Abstract Number: PB0361

Coxsackievirus B3 infection of CD34+ cells impairs megakaryocyte and platelet production through activation of Toll-like receptors 7 and 8

M. Schattner1, C. Rodriguez2, N. Charo3, S. Tatti4, R. Gomez5, L. D'Atri6

Abstract Number: PB0359

CRISPR genome editing coupled with optimized biomanufactured human platelets for molecular and functional investigation of platelet biogenesis.

L. Mallo1, A. Pongerard1, C. GACHET1, Y. KNAPP2, F. Lanza1, C. Strassel1

Abstract Number: VPB0364

Defective megakaryopoiesis in ETV6-variant carriers results from an aberrant megakaryocyte-erythroid progenitor population

T. Bigot1, E. Gabinaud1, L. Hannouche1, V. Sbarra1, D. Payet-Bornet2, M. Loosveld3, D. Potier2, M. Alessi1, M. Poggi1

Abstract Number: VPB0365

Differential Autoregulation of RUNX1 by Isoforms RUNX1 B and RUNX1 C in Megakaryocytic Cells

L. Guan1, A. Rao2

Abstract Number: OC 59.5

Glucocorticoids Stimulate Thrombopoiesis in Murine Megakaryocytes

M. Grodzielski, J. Cidlowski

Abstract Number: OC 75.2

GP1b-FilaminA interaction regulates megakaryocyte localization and budding during platelet biogenesis

M. Ellis1, A. Terreaux2, R. Smythe3, A. Eckly4, S. Cranmer5, J. Maclean3, I. Alwis3, J. Perdomo6, F. Passam1, S. Taoudi2, F. Lanza7, Y. Yuan8, J. Shaun1

Abstract Number: PB0358

In-depth analysis of the effects of unsteady flows on platelet release from suspensions of proplatelet-bearing megakaryocytes

O. Boiron1, F. Lanza2, C. Strassel2, Y. KNAPP3

Abstract Number: OC 75.4

Investigating the health and function of murine platelets generated using a new ex-vivo lung system

N. Tarassova, X. Zhao, A. Poole

Abstract Number: PB0355

Knockdown screening of microRNAs in thrombocytes and their role in thrombopoiesis

A. Al Qaryoute, W. Fallatah, S. Dhinoja, P. Jagadeeswaran

Abstract Number: OC 35.1

Light-induced Ca2+ signaling triggers megakaryocyte polarization

Y. Zhang1, S. Gao2, J. Yu-Strzelczyk2, H. Kurz3, G. Nagel4, M. Bender5

Abstract Number: OC 59.3

Megakaryocyte Engraftment and altered Platelet Function in a Murine Model of Hematopoietic Stem Cell Transplantation

K. Mott1, C. Keß2, A. Frank2, S. Hölle3, Z. Nagy2, N. Schlegel4, M. Eyrich3, H. Schulze5

Abstract Number: PB0357

Megakaryocyte-Driven Blood Clot Contraction and its Structural Mechanisms

O. Kim1, A. Gagne2, R. Litvinov3, D. French2, L. Brass4, J. Weisel1

Abstract Number: PB0362

Molecular insights into the cause and treatment of congenital thrombocytopenia in mice lacking the co-inhibitory receptor G6b-B

A. MAZHARIAN1, B. Maître2, D. Hennequin3, M. Lourenco-Rodrigues4, S. Heising5, H. De la salle6, S. Watson7, C. GACHET2, Y. Senis8

Abstract Number: OC 59.4

Novel variants in GALE caused syndromic macrothrombocytopenia disrupting thrombopoiesis and glycosylation

A. Marin-Quilez1, C. Di Buduo2, L. Díaz-Ajenjo1, P. Soprano3, E. Vuelta1, I. Serramito-Gómez1, S. Santos-Mínguez1, C. Miguel-García1, S. Tocino-Antonio4, A. Zamora-Canovas5, P. Ruiz-Sala6, M. Peñarrubia7, E. Pardal8, J. Hernández-Rivas9, J. González-Porras10, R. Benito1, J. Rivera11, I. García-Tuñón1, A. Balduini12, J. Bastida13

Abstract Number: PB0363

Phosphoinositide dynamics in megakaryocyte/platelet granule integrity and platelet functions

S. Severin1, M. Caux2, R. Mansour2, J. Xuereb2, G. Chicanne2, J. Viaud2, A. Vauclard2, F. Boal2, B. Payrastre2, H. Tronchere2

Abstract Number: OC 75.3

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

X. Zhao1, D. Alibhai1, T. Walsh1, N. Tarassova1, S. Birol1, C. Williams1, C. Neal1, E. Aitken1, A. Waller2, J. Ballester-Beltran3, P. Gunning4, E. Hardeman5, E. Agbani6, I. Hers1, C. Ghevaert3, A. Poole1

Abstract Number: OC 75.5

Platelet release device: From bench-scale to large culture platelet production

A. Pongerard1, L. Mallo1, V. Do Sacramento1, O. Boiron2, F. Lanza1, C. GACHET1, Y. KNAPP3, C. Strassel1

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