Platelets and Megakaryocytes » Megakaryocytes and Thrombopoiesis

Abstract Number: OC 75.1

A 3D microvasculature assay reveals novel sub-cellular dynamics of megakaryocyte endothelial barrier interactions, proplatelet formation and release.

N. Asquith¹, D. Freire¹, S. Shelton², K. Machlus³, R. Kamm², J. Italiano⁴

Abstract Number: OC 26.2

A dose-escalation phase 1 clinical trial of autologous iPSC-derived platelets (iPLAT1)

N. Sugimoto¹, J. kanda², S. Nakamura³, T. Kitano², S. Shimizu¹, A. Shigemasa¹, H. Hirai², M. Minami², H. Tada², D. Momose⁴, K. Koh⁴, M. Nogawa⁵, N. Watanabe⁶, M. Handa⁶, A. Sawaguchi⁷, M. Tanaka⁸, T. Hayashi⁸, Y. Tani⁸, A. Takaori-Kondo⁹, K. Eto³

Abstract Number: OC 10.3

A novel model of RUNX1-haploinsufficient (RUNX1Lo): Human megakaryocytes infused into mice further characterizes this defect and identifies potential therapeutics

K. Lee, H. Ahn, M. Poncz

Abstract Number: PB0361

Coxsackievirus B3 infection of CD34+ cells impairs megakaryocyte and platelet production through activation of Toll-like receptors 7 and 8

M. Schattner¹, C. Rodriguez², N. Charo³, S. Tatti⁴, R. Gomez⁵, L. D'Atri⁶

Abstract Number: PB0359

CRISPR genome editing coupled with optimized biomanufactured human platelets for molecular and functional investigation of platelet biogenesis.

L. Mallo¹, A. Pongerard¹, C. GACHET¹, Y. KNAPP², F. Lanza¹, C. Strassel¹

Abstract Number: VPB0364

Defective megakaryopoiesis in ETV6-variant carriers results from an aberrant megakaryocyte-erythroid progenitor population

T. Bigot¹, E. Gabinaud¹, L. Hannouche¹, V. Sbarra¹, D. Payet-Bornet², M. Loosveld³, D. Potier², M. Alessi¹, M. Poggi¹

Abstract Number: VPB0365

Differential Autoregulation of RUNX1 by Isoforms RUNX1 B and RUNX1 C in Megakaryocytic Cells

L. Guan¹, A. Rao²

Abstract Number: OC 59.5

Glucocorticoids Stimulate Thrombopoiesis in Murine Megakaryocytes

M. Grodzielski, J. Cidlowski

Abstract Number: OC 75.2

GP1b-FilaminA interaction regulates megakaryocyte localization and budding during platelet biogenesis

M. Ellis¹, A. Terreaux², R. Smythe³, A. Eckly⁴, S. Cranmer⁵, J. Maclean³, I. Alwis³, J. Perdomo⁶, F. Passam¹, S. Taoudi², F. Lanza⁷, Y. Yuan⁸, J. Shaun¹

Abstract Number: PB0358

In-depth analysis of the effects of unsteady flows on platelet release from suspensions of proplatelet-bearing megakaryocytes

O. Boiron¹, F. Lanza², C. Strassel², Y. KNAPP³

Abstract Number: OC 75.4

Investigating the health and function of murine platelets generated using a new ex-vivo lung system

N. Tarassova, X. Zhao, A. Poole

Abstract Number: PB0355

Knockdown screening of microRNAs in thrombocytes and their role in thrombopoiesis

A. Al Qaryoute, W. Fallatah, S. Dhinoja, P. Jagadeeswaran

Abstract Number: OC 35.1

Light-induced Ca2+ signaling triggers megakaryocyte polarization

Y. Zhang¹, S. Gao², J. Yu-Strzelczyk², H. Kurz³, G. Nagel⁴, M. Bender⁵

Abstract Number: OC 59.3

Megakaryocyte Engraftment and altered Platelet Function in a Murine Model of Hematopoietic Stem Cell Transplantation

K. Mott¹, C. Keß², A. Frank², S. Hölle³, Z. Nagy², N. Schlegel⁴, M. Eyrich³, H. Schulze⁵

Abstract Number: PB0357

Megakaryocyte-Driven Blood Clot Contraction and its Structural Mechanisms

O. Kim¹, A. Gagne², R. Litvinov³, D. French², L. Brass⁴, J. Weisel¹

Abstract Number: PB0362

Molecular insights into the cause and treatment of congenital thrombocytopenia in mice lacking the co-inhibitory receptor G6b-B

A. MAZHARIAN¹, B. Maître², D. Hennequin³, M. Lourenco-Rodrigues⁴, S. Heising⁵, H. De la salle⁶, S. Watson⁷, C. GACHET², Y. Senis⁸

Abstract Number: OC 59.4

Novel variants in GALE caused syndromic macrothrombocytopenia disrupting thrombopoiesis and glycosylation

A. Marin-Quilez¹, C. Di Buduo², L. Díaz-Ajenjo¹, P. Soprano³, E. Vuelta¹, I. Serramito-Gómez¹, S. Santos-Mínguez¹, C. Miguel-García¹, S. Tocino-Antonio⁴, A. Zamora-Canovas⁵, P. Ruiz-Sala⁶, M. Peñarrubia⁷, E. Pardal⁸, J. Hernández-Rivas⁹, J. González-Porras¹⁰, R. Benito¹, J. Rivera¹¹, I. García-Tuñón¹, A. Balduini¹², J. Bastida¹³

Abstract Number: PB0363

Phosphoinositide dynamics in megakaryocyte/platelet granule integrity and platelet functions

S. Severin¹, M. Caux², R. Mansour², J. Xuereb², G. Chicanne², J. Viaud², A. Vauclard², F. Boal², B. Payrastre², H. Tronchere²

Abstract Number: OC 75.3

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

X. Zhao¹, D. Alibhai¹, T. Walsh¹, N. Tarassova¹, S. Birol¹, C. Williams¹, C. Neal¹, E. Aitken¹, A. Waller², J. Ballester-Beltran³, P. Gunning⁴, E. Hardeman⁵, E. Agbani⁶, I. Hers¹, C. Ghevaert³, A. Poole¹

Abstract Number: OC 75.5

Platelet release device: From bench-scale to large culture platelet production

A. Pongerard¹, L. Mallo¹, V. Do Sacramento¹, O. Boiron², F. Lanza¹, C. GACHET¹, Y. KNAPP³, C. Strassel¹