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ISTH 2022 Congress

Platelets and Megakaryocytes » Platelet Receptors

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  • ISTH 2022 Congress
    • Platelets and Megakaryocytes
      • Platelet Receptors

Abstract Number: OC 41.5

A novel and unique mechanism of αIIbβ3 regulation in platelets

C. Kusch1, D. Stegner2, D. Johnson3, M. Meub4, P. Nurden5, C. Gross6, D. Semeniak6, J. Schenk7, M. Bender8, T. Vögtle9, K. Heinze7, M. Sauer10, A. Nurden5, B. Nieswandt8

Abstract Number: OC 10.2

Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model

H. Brown1, S. Beck2, S. Navarro1, S. Watson3, B. Nieswandt4, D. Stegner5

Abstract Number: OC 77.5

Comprehensive analysis of human glycoprotein Ibα O-glycosylation.

M. Hollenhorst1, K. Tiemeyer1, K. Mahoney2, K. Aoki3, M. Ishihara3, V. Rangel-Angarita2, C. Bertozzi4, S. Malaker2

Abstract Number: PB0375

Deciphering the TLT-1 Fibrinogen ligand interaction.

s. Branfield1, X. Vales2, A. Washington3, C. wu4, P. Akamine2, J. González2

Abstract Number: PB0379

Functional expression of GFP-tagged integrin αIIb in a transgenic (knockin) mouse line

C. Kusch1, D. Johnson2, P. Burkard3, P. Öftering3, D. Stegner4, S. Beck5, B. Nieswandt6

Abstract Number: PB0385

GPIbα shedding is restricted to the inner platelet membrane

K. Six1, M. Van den Hauwe2, R. De Rycke3, I. Sagi4, E. Gardiner5, V. Compernolle6, H. Feys7

Abstract Number: PB0387

GPR56 is the platelet collagen receptor activator of G protein 13

L. Pan1, T. Bernadyn2, R. Adili3, M. Holinstat4, G. Tall2

Abstract Number: PB0384

GPVI is a binding site for factor VIII on platelets

R. Sekar1, A. Mimoun2, M. Bou Jaoudeh3, S. Loyau4, S. Delignat5, V. Daventure5, J. Rayes6, Y. Boulaftali7, M. Jandrot-Perrus8, V. Proulle9, S. Lacroix-Desmazes10

Abstract Number: PB0377

Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kbeta

C. Kardeby1, A. Evans1, J. Campos1, C. Smith1, A. Slater1, E. Martin1, S. Severin2, A. Brill1, G. Pejler3, Y. Sun1, S. Watson4

Abstract Number: PB0391

Human platelets do not express a functional FcERI receptor on their surface

C. TACQUARD1, F. TUPIN2, S. MAGNENAT3, C. METZ-FAVRE4, P. MERTES5, C. GACHET3, B. HECHLER3

Abstract Number: PB0390

Identification of novel inhibitors of the platelet collagen receptor GPVI by a phenotypic screening assay

S. Troitiño1, I. Izquierdo2, N. Gómez-Romero2, F. Rodríguez Del Río2, G. Prieto Da Cuña2, L. Hermida-Nogueira1, E. Domínguez3, M. Loza4, Á. García1

Abstract Number: PB0381

Impact of Coagulation Factor XI (FXI) on the Binding of Platelet Glycoprotein Ibα to the von Willebrand Factor A1 Domain

M. Nakayama1, S. Goto2, S. Takemoto3, H. Oka2, H. Yokota3, S. Takagi4

Abstract Number: PB0383

Increased platelet procoagulant activity driven by fibrin-GPVI interaction alters clot structure

J. Sandrin Gauer1, C. Duval2, R. Xu3, F. Macrae2, C. Tiede2, D. Tomlinson2, S. Watson4, R. Ariëns5

Abstract Number: PB0376

Inhibition of the p75 pan neurotrophic receptor partly mitigates BDNF-induced platelet aggregation

S. Fleury1, I. Boukhatem2, M. Welman1, É. Maurand3, B. Allen1, H. Saragovi4, M. Lordkipanidzé1

Abstract Number: VPB0394

iPSC-Derived Megakaryocytes as a Model to Study Human Platelet Integrin IIb3 Function

K. Fong1, O. Kim2, A. Gagne3, C. Jobaliya3, J. Maguire3, M. Poncz4, D. French3, R. Litvinov5, J. Weisel6, W. Degrado7, L. Brass1

Abstract Number: OC 77.4

Pharmacological targeting of GPV in a novel humanized mouse model to modulate thrombus formation in vivo

P. Öftering1, S. Beck2, D. Stegner3, B. Nieswandt4

Abstract Number: PB0392

Pim kinase: A novel regulator of platelet and megakaryocyte thromboxane A2 and C-X-C-R motif receptors

S. Nock1, L. Hutchinson2, K. Naseem3, S. Jones1, S. Mundell2, A. Unsworth4, M. blanco-Lopez1

Abstract Number: PB0380

Platelet glycoprotein analysis by flow cytometry, could further diagnostic information be gained from the mean fluorescence intensity values?

A. McCormick, O. Galvez, S. Nasim, M. Panetta, Y. Daniel

Abstract Number: PB0388

Platelet glycoprotein Ibα carries ABO blood group antigens

K. Tiemeyer1, M. Hollenhorst1, K. Aoki2, M. Ishihara2, C. Bertozzi3

Abstract Number: OC 41.1

Platelet αIIbβ3 integrin is produced in different covalent forms that have different functions

A. Pijning1, M. Blyth2, M. Coote2, F. Passam3, J. Chiu4, P. Hogg4

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