Platelets and Megakaryocytes » Platelet Receptors

Abstract Number: OC 41.5

A novel and unique mechanism of αIIbβ3 regulation in platelets

C. Kusch¹, D. Stegner², D. Johnson³, M. Meub⁴, P. Nurden⁵, C. Gross⁶, D. Semeniak⁶, J. Schenk⁷, M. Bender⁸, T. Vögtle⁹, K. Heinze⁷, M. Sauer¹⁰, A. Nurden⁵, B. Nieswandt⁸

Abstract Number: OC 10.2

Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model

H. Brown¹, S. Beck², S. Navarro¹, S. Watson³, B. Nieswandt⁴, D. Stegner⁵

Abstract Number: OC 77.5

Comprehensive analysis of human glycoprotein Ibα O-glycosylation.

M. Hollenhorst¹, K. Tiemeyer¹, K. Mahoney², K. Aoki³, M. Ishihara³, V. Rangel-Angarita², C. Bertozzi⁴, S. Malaker²

Abstract Number: PB0375

Deciphering the TLT-1 Fibrinogen ligand interaction.

s. Branfield¹, X. Vales², A. Washington³, C. wu⁴, P. Akamine², J. González²

Abstract Number: PB0379

Functional expression of GFP-tagged integrin αIIb in a transgenic (knockin) mouse line

C. Kusch¹, D. Johnson², P. Burkard³, P. Öftering³, D. Stegner⁴, S. Beck⁵, B. Nieswandt⁶

Abstract Number: PB0385

GPIbα shedding is restricted to the inner platelet membrane

K. Six¹, M. Van den Hauwe², R. De Rycke³, I. Sagi⁴, E. Gardiner⁵, V. Compernolle⁶, H. Feys⁷

Abstract Number: PB0387

GPR56 is the platelet collagen receptor activator of G protein 13

L. Pan¹, T. Bernadyn², R. Adili³, M. Holinstat⁴, G. Tall²

Abstract Number: PB0384

GPVI is a binding site for factor VIII on platelets

R. Sekar¹, A. Mimoun², M. Bou Jaoudeh³, S. Loyau⁴, S. Delignat⁵, V. Daventure⁵, J. Rayes⁶, Y. Boulaftali⁷, M. Jandrot-Perrus⁸, V. Proulle⁹, S. Lacroix-Desmazes¹⁰

Abstract Number: PB0377

Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kbeta

C. Kardeby¹, A. Evans¹, J. Campos¹, C. Smith¹, A. Slater¹, E. Martin¹, S. Severin², A. Brill¹, G. Pejler³, Y. Sun¹, S. Watson⁴

Abstract Number: PB0391

Human platelets do not express a functional FcERI receptor on their surface

C. TACQUARD¹, F. TUPIN², S. MAGNENAT³, C. METZ-FAVRE⁴, P. MERTES⁵, C. GACHET³, B. HECHLER³

Abstract Number: PB0390

Identification of novel inhibitors of the platelet collagen receptor GPVI by a phenotypic screening assay

S. Troitiño¹, I. Izquierdo², N. Gómez-Romero², F. Rodríguez Del Río², G. Prieto Da Cuña², L. Hermida-Nogueira¹, E. Domínguez³, M. Loza⁴, Á. García¹

Abstract Number: PB0381

Impact of Coagulation Factor XI (FXI) on the Binding of Platelet Glycoprotein Ibα to the von Willebrand Factor A1 Domain

M. Nakayama¹, S. Goto², S. Takemoto³, H. Oka², H. Yokota³, S. Takagi⁴

Abstract Number: PB0383

Increased platelet procoagulant activity driven by fibrin-GPVI interaction alters clot structure

J. Sandrin Gauer¹, C. Duval², R. Xu³, F. Macrae², C. Tiede², D. Tomlinson², S. Watson⁴, R. Ariëns⁵

Abstract Number: PB0376

Inhibition of the p75 pan neurotrophic receptor partly mitigates BDNF-induced platelet aggregation

S. Fleury¹, I. Boukhatem², M. Welman¹, É. Maurand³, B. Allen¹, H. Saragovi⁴, M. Lordkipanidzé¹

Abstract Number: VPB0394

iPSC-Derived Megakaryocytes as a Model to Study Human Platelet Integrin IIb3 Function

K. Fong¹, O. Kim², A. Gagne³, C. Jobaliya³, J. Maguire³, M. Poncz⁴, D. French³, R. Litvinov⁵, J. Weisel⁶, W. Degrado⁷, L. Brass¹

Abstract Number: OC 77.4

Pharmacological targeting of GPV in a novel humanized mouse model to modulate thrombus formation in vivo

P. Öftering¹, S. Beck², D. Stegner³, B. Nieswandt⁴

Abstract Number: PB0392

Pim kinase: A novel regulator of platelet and megakaryocyte thromboxane A2 and C-X-C-R motif receptors

S. Nock¹, L. Hutchinson², K. Naseem³, S. Jones¹, S. Mundell², A. Unsworth⁴, M. blanco-Lopez¹

Abstract Number: PB0380

Platelet glycoprotein analysis by flow cytometry, could further diagnostic information be gained from the mean fluorescence intensity values?

A. McCormick, O. Galvez, S. Nasim, M. Panetta, Y. Daniel

Abstract Number: PB0388

Platelet glycoprotein Ibα carries ABO blood group antigens

K. Tiemeyer¹, M. Hollenhorst¹, K. Aoki², M. Ishihara², C. Bertozzi³

Abstract Number: OC 41.1

Platelet αIIbβ3 integrin is produced in different covalent forms that have different functions

A. Pijning¹, M. Blyth², M. Coote², F. Passam³, J. Chiu⁴, P. Hogg⁴