Platelets and Megakaryocytes

Abstract Number: OC 75.1

A 3D microvasculature assay reveals novel sub-cellular dynamics of megakaryocyte endothelial barrier interactions, proplatelet formation and release.

N. Asquith¹, D. Freire¹, S. Shelton², K. Machlus³, R. Kamm², J. Italiano⁴

Abstract Number: OC 26.2

A dose-escalation phase 1 clinical trial of autologous iPSC-derived platelets (iPLAT1)

N. Sugimoto¹, J. kanda², S. Nakamura³, T. Kitano², S. Shimizu¹, A. Shigemasa¹, H. Hirai², M. Minami², H. Tada², D. Momose⁴, K. Koh⁴, M. Nogawa⁵, N. Watanabe⁶, M. Handa⁶, A. Sawaguchi⁷, M. Tanaka⁸, T. Hayashi⁸, Y. Tani⁸, A. Takaori-Kondo⁹, K. Eto³

Abstract Number: OC 49.3

A microfluidic model to study the initiation of venous thrombosis

L. Mereweather¹, J. van Batenburg-Sherwood¹, J. Ahnström¹, I. Salles-Crawley², J. Crawley¹

Abstract Number: OC 41.5

A novel and unique mechanism of αIIbβ3 regulation in platelets

C. Kusch¹, D. Stegner², D. Johnson³, M. Meub⁴, P. Nurden⁵, C. Gross⁶, D. Semeniak⁶, J. Schenk⁷, M. Bender⁸, T. Vögtle⁹, K. Heinze⁷, M. Sauer¹⁰, A. Nurden⁵, B. Nieswandt⁸

Abstract Number: OC 10.3

A novel model of RUNX1-haploinsufficient (RUNX1Lo): Human megakaryocytes infused into mice further characterizes this defect and identifies potential therapeutics

K. Lee, H. Ahn, M. Poncz

Abstract Number: OC 10.5

Aging Activates Platelet mTOR to Induce Platelet Hyperreactivity

I. Portier, B. Manne, Y. Kosaka, F. Denorme, R. Campbell

Abstract Number: PB0886

Alcohol intake including wine drinking is associated with decreased platelet reactivity in a large population sample

R. Pashek¹, B. Nkambule², M. Chan³, F. Thibord⁴, A. Lachapelle³, J. Cunha⁵, M. Chen³, A. Johnson³

Abstract Number: VPB0373

Alteration of circulating platelet-related and diabetes-related microRNAs in individuals with type 2 diabetes: Results from a stepwise hypoglycaemic clamp study

C. Eyileten¹, Z. Wicik¹, D. Keshwani¹, A. Nowak¹, F. Aziz², F. Aberer², P. Pferschy², N. Tripolt², C. Sourij², B. Prietl², F. Prüller², D. Von Lewinski², J. Siller-Matula³, M. Postula¹, H. Sourij²

Abstract Number: OC 09.2

An Extensional Strain-Sensing Mechanosome Drives Rapid Adhesion-Independent Platelet Activation at Supraphysiological Hemodynamic Gradients

N. Zainal Abidin¹, E. Poon², C. Szydzik³, M. Timofeeva⁴, F. Akbaridoust⁴, R. Brazilek³, F. Tovar Lopez⁵, X. Ma⁶, C. Lav⁴, I. Marusic⁴, P. Thompson⁶, A. Mitchell⁵, A. Ooi⁴, J. Hamilton³, W. Nesbitt³

Abstract Number: PB0888

Anaphylactic Shock To A Hematological Disorder Patient During Transfusion Of Platelet Aphaeresis Unit Stored In Platelet Additive Solution: A Rare Case Report

B. poluru mranikrinda

Abstract Number: OC 33.5

Anti-PF4 IgG levels in patients with VITT remain high at 7 months following vaccination and can still activate platelets

S. Montague¹, C. Smith², C. Lodwick³, C. Stoneley⁴, M. Roberts⁴, G. Lowe⁵, W. Lester⁴, S. Watson¹, P. Nicolson⁶

Abstract Number: OC 10.2

Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model

H. Brown¹, S. Beck², S. Navarro¹, S. Watson³, B. Nieswandt⁴, D. Stegner⁵

Abstract Number: PB0874

Assessing Circulation Persistence of Human Platelet Products in a NOD-SCID Mouse Model

B. Kuhn¹, K. Moskowitz²

Abstract Number: PB0395

Avidity-dependent differential signaling by CLEC-2 receptors

S. Kunapuli¹, C. Dangelmaier¹, J. Kostyak²

Abstract Number: PB0881

Calcium-and integrin-binding protein 2 negatively regulates in vivo thrombosis and platelet functions by attenuating S1P production

M. Naik, K. Golla, N. Shaik, P. Patel, U. Naik

Abstract Number: OC 10.1

CD36-dependent metabolic rewiring and mitochondrial dysfunction in platelets in response to hyperlipidaemia.

L. Cheah, M. Hindle, K. Naseem

Abstract Number: PB0895

Changes in immature platelet fraction after major trauma: a prospective cohort study

A. Rossetto¹, P. Armstrong², L. Green³, K. Brohi⁴, T. Warner², P. Vulliamy⁵

Abstract Number: PB0370

Characterization of the human platelet glycome upon storage using tandem mass spectrometry

M. Lee-Sundlov¹, R. Grozovsky², A. Hanneman³, K. Hoffmeister¹

Abstract Number: PB0848

Characterization of the uric acid transporter URAT1 (SLC22A12) in platelets and megakaryocytes

I. Boukhatem¹, J. Bélanger², O. Ghafoud², S. Fleury³, M. Welman³, M. Lordkipanidzé³

Abstract Number: PB0396

Characterization of thrombogenic effects of platelet tyrosine phosphatase SHP2 inhibition using the allosteric inhibitor SHP099

D. Fernández de la Fuente¹, L. Hermida-Nogueira², J. Huang³, S. Veiras⁴, M. Kuijpers⁵, J. Heemskerk⁶, Á. García²