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ISTH 2022 Congress

Platelets and Megakaryocytes

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  • ISTH 2022 Congress
    • Platelets and Megakaryocytes
      • Megakaryocytes and Thrombopoiesis
      • Platelet Function and Interactions
      • Platelet Proteomics and Genomics
      • Platelet Receptors
      • Platelet Signaling

Abstract Number: OC 75.1

A 3D microvasculature assay reveals novel sub-cellular dynamics of megakaryocyte endothelial barrier interactions, proplatelet formation and release.

N. Asquith1, D. Freire1, S. Shelton2, K. Machlus3, R. Kamm2, J. Italiano4

Abstract Number: OC 26.2

A dose-escalation phase 1 clinical trial of autologous iPSC-derived platelets (iPLAT1)

N. Sugimoto1, J. kanda2, S. Nakamura3, T. Kitano2, S. Shimizu1, A. Shigemasa1, H. Hirai2, M. Minami2, H. Tada2, D. Momose4, K. Koh4, M. Nogawa5, N. Watanabe6, M. Handa6, A. Sawaguchi7, M. Tanaka8, T. Hayashi8, Y. Tani8, A. Takaori-Kondo9, K. Eto3

Abstract Number: OC 49.3

A microfluidic model to study the initiation of venous thrombosis

L. Mereweather1, J. van Batenburg-Sherwood1, J. Ahnström1, I. Salles-Crawley2, J. Crawley1

Abstract Number: OC 41.5

A novel and unique mechanism of αIIbβ3 regulation in platelets

C. Kusch1, D. Stegner2, D. Johnson3, M. Meub4, P. Nurden5, C. Gross6, D. Semeniak6, J. Schenk7, M. Bender8, T. Vögtle9, K. Heinze7, M. Sauer10, A. Nurden5, B. Nieswandt8

Abstract Number: OC 10.3

A novel model of RUNX1-haploinsufficient (RUNX1Lo): Human megakaryocytes infused into mice further characterizes this defect and identifies potential therapeutics

K. Lee, H. Ahn, M. Poncz

Abstract Number: OC 10.5

Aging Activates Platelet mTOR to Induce Platelet Hyperreactivity

I. Portier, B. Manne, Y. Kosaka, F. Denorme, R. Campbell

Abstract Number: PB0886

Alcohol intake including wine drinking is associated with decreased platelet reactivity in a large population sample

R. Pashek1, B. Nkambule2, M. Chan3, F. Thibord4, A. Lachapelle3, J. Cunha5, M. Chen3, A. Johnson3

Abstract Number: VPB0373

Alteration of circulating platelet-related and diabetes-related microRNAs in individuals with type 2 diabetes: Results from a stepwise hypoglycaemic clamp study

C. Eyileten1, Z. Wicik1, D. Keshwani1, A. Nowak1, F. Aziz2, F. Aberer2, P. Pferschy2, N. Tripolt2, C. Sourij2, B. Prietl2, F. Prüller2, D. Von Lewinski2, J. Siller-Matula3, M. Postula1, H. Sourij2

Abstract Number: OC 09.2

An Extensional Strain-Sensing Mechanosome Drives Rapid Adhesion-Independent Platelet Activation at Supraphysiological Hemodynamic Gradients

N. Zainal Abidin1, E. Poon2, C. Szydzik3, M. Timofeeva4, F. Akbaridoust4, R. Brazilek3, F. Tovar Lopez5, X. Ma6, C. Lav4, I. Marusic4, P. Thompson6, A. Mitchell5, A. Ooi4, J. Hamilton3, W. Nesbitt3

Abstract Number: PB0888

Anaphylactic Shock To A Hematological Disorder Patient During Transfusion Of Platelet Aphaeresis Unit Stored In Platelet Additive Solution: A Rare Case Report

B. poluru mranikrinda

Abstract Number: OC 33.5

Anti-PF4 IgG levels in patients with VITT remain high at 7 months following vaccination and can still activate platelets

S. Montague1, C. Smith2, C. Lodwick3, C. Stoneley4, M. Roberts4, G. Lowe5, W. Lester4, S. Watson1, P. Nicolson6

Abstract Number: OC 10.2

Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model

H. Brown1, S. Beck2, S. Navarro1, S. Watson3, B. Nieswandt4, D. Stegner5

Abstract Number: PB0874

Assessing Circulation Persistence of Human Platelet Products in a NOD-SCID Mouse Model

B. Kuhn1, K. Moskowitz2

Abstract Number: PB0395

Avidity-dependent differential signaling by CLEC-2 receptors

S. Kunapuli1, C. Dangelmaier1, J. Kostyak2

Abstract Number: PB0881

Calcium-and integrin-binding protein 2 negatively regulates in vivo thrombosis and platelet functions by attenuating S1P production

M. Naik, K. Golla, N. Shaik, P. Patel, U. Naik

Abstract Number: OC 10.1

CD36-dependent metabolic rewiring and mitochondrial dysfunction in platelets in response to hyperlipidaemia.

L. Cheah, M. Hindle, K. Naseem

Abstract Number: PB0895

Changes in immature platelet fraction after major trauma: a prospective cohort study

A. Rossetto1, P. Armstrong2, L. Green3, K. Brohi4, T. Warner2, P. Vulliamy5

Abstract Number: PB0370

Characterization of the human platelet glycome upon storage using tandem mass spectrometry

M. Lee-Sundlov1, R. Grozovsky2, A. Hanneman3, K. Hoffmeister1

Abstract Number: PB0848

Characterization of the uric acid transporter URAT1 (SLC22A12) in platelets and megakaryocytes

I. Boukhatem1, J. Bélanger2, O. Ghafoud2, S. Fleury3, M. Welman3, M. Lordkipanidzé3

Abstract Number: PB0396

Characterization of thrombogenic effects of platelet tyrosine phosphatase SHP2 inhibition using the allosteric inhibitor SHP099

D. Fernández de la Fuente1, L. Hermida-Nogueira2, J. Huang3, S. Veiras4, M. Kuijpers5, J. Heemskerk6, Á. García2

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